Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics

…, Alzheimer's Disease Neuroimaging Initiative (ADNI)… - Brain, 2020 - academic.oup.com
… ) of Alzheimer's disease polygenic risk scores for increasing SNP inclusion P-value thresholds,
comparing Alzheimer's disease … of Alzheimer's disease subtypes in Alzheimer's disease

Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: a literature review

KEJ Wesenhagen, CE Teunissen… - Critical reviews in …, 2020 - Taylor & Francis
… to study AD disease mechanisms. Here, we review the CSF proteomics literature to identify
… on these proteins to study which biological processes may be involved in the disease. …

Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease

M Puchades, SF Hansson, CL Nilsson… - Molecular brain …, 2003 - Elsevier
… By comparing the cerebrospinal fluid (CSF) proteome between Alzheimer's disease (AD)
patients and controls, it may be possible to identify proteins that play a role in the disease

Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease

EJ Finehout, Z Franck, LH Choe… - Annals of Neurology …, 2007 - Wiley Online Library
… To find a panel of proteins in antemortem cerebrospinal fluid (CSF) that could be used to
differentiate between samples from Alzheimer's disease (AD) patients and samples from …

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

JM Bader, PE Geyer, JB Müller, MT Strauss… - Molecular systems …, 2020 - embopress.org
Alzheimer's disease (AD) patients have higher CSF levels of … spectrometry (MS)-based
proteomics workflow for the in-depth … CSF proteome changes in Alzheimer's disease prove to be …

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

L Higginbotham, L Ping, EB Dammer, DM Duong… - Science …, 2020 - science.org
… Here, we used integrative proteomics to identify cerebrospinal fluid (CSF) biomarkers …
proteome resolved 44 biologically diverse modules, 15 of which overlapped with the CSF proteome

[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

ECB Johnson, S Bian, RU Haque, EK Carter… - Nature medicine, 2023 - nature.com
… evolve over the course of the disease is currently unknown. Here we show that proteomic
measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein …

[HTML][HTML] Analysis of the cerebrospinal fluid proteome in Alzheimer's disease

PE Khoonsari, A Häggmark, M Lönnberg, M Mikus… - PloS one, 2016 - journals.plos.org
… detection, they are not suitable for monitor of diseasefluid proteome of Alzheimer’s disease
patients and non-demented controls to identify potential biomarkers for Alzheimer’s disease. …

[HTML][HTML] Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles

BM Tijms, EM Vromen, O Mjaavatten, H Holstege… - Nature aging, 2024 - nature.com
… Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal
fluid, based on 1,058 proteins, with different levels in individuals with AD (n = 419) …

[HTML][HTML] Neurodegeneration and Alzheimer's disease (AD). What can proteomics tell us about the Alzheimer's brain?

G Moya-Alvarado, N Gershoni-Emek, E Perlson… - … & Cellular Proteomics, 2016 - ASBMB
… cellular proteome that could provide insight into disease etiology … to how and whether
proteomics studies have contributed to … , several candidate cerebrospinal fluid biomarkers are now …