… enhanced our understanding of AD genetic architecture, heritability estimates from … that
our understanding of AD genetic architecture and genetic risk mechanisms remains incomplete. …

… the underlying genetic architecture of both forms of the disease, … As no disease-modifying
intervention currently exists, … functional genetic architecture) across the spectrum of disease is …

Alzheimer’s disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

… Historically, Alzheimer's disease (AD) is … genetics of Alzheimer's disease is complex and
heterogeneous. Most cases are “sporadic” with no apparent familial recurrence of the disease. …

… after Alzheimer's disease (AD). The heterogeneity of these disorders and/or the clinical overlap
with other diseases hinder the study of their genetic … of these forms of disease can have a …

… Alzheimer's disease is a genetically complex disorder. For 17 years, APOE was the only
known susceptibility gene for disease… with late-onset Alzheimer's disease. These susceptibility …

… variants associated with AD risk and not on other aspects of the disease, such as age at …
the genetic architecture of these phenotypes. We hypothesized that the genetic architecture of …

… a genetic association between Alzheimer's disease and a well-defined subgroup of depression
cases characterized by late-life onset. Many studies indicate that late-life depression may …

Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358
polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease …

… of genetic and environmental effects. In this study, we specifically focused on the genetic
architecture that characterizes the genetic … the collective effects of multiple genetic risk variants (…