Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

P Talwar, Y Silla, S Grover, M Gupta, R Agarwal… - BMC genomics, 2014 - Springer
… This analysis yielded 108 plausible AD genes. Network modelling by creating PPI using
proteins encoded by these genes and their direct interactors resulted in a layered network of …

Network analysis of intrinsic functional brain connectivity in Alzheimer's disease

K Supekar, V Menon, D Rubin, M Musen… - PLoS computational …, 2008 - journals.plos.org
… Moreover, our results indicate that cognitive decline in Alzheimer's disease patients is
associated with disrupted functional connectivity in the entire brain. Our findings further suggest …

The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target

VA Petyuk, R Chang, M Ramirez-Restrepo… - Brain, 2018 - academic.oup.com
… As network analysis is based on correlative structures and not … in late-onset Alzheimer’s
disease pathogenesis (ie the two … ; increased expression in Alzheimer's disease. …

Breakdown of Brain Connectivity Between Normal Aging and Alzheimer's Disease: A Structural k-Core Network Analysis

…, PM Thompson, for the Alzheimer's Disease … - Brain …, 2013 - liebertpub.com
… and Alzheimer's disease (AD). Even so, we know very little about how the brain's networks
… We computed a variety of measures sensitive to anatomical network topology, including the …

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

M Wang, P Roussos, A McKenzie, X Zhou, Y Kajiwara… - Genome medicine, 2016 - Springer
… Gene co-expression network analysis … -expression network analysis (WGCNA) to capture
the coordinated gene expression for each brain region separately. The co-expression networks

Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

ECB Johnson, EB Dammer, DM Duong, L Yin… - Molecular …, 2018 - Springer
… of our proteomic network analysis of AD brain by approximately a factor of three using a new
TMT-based analysis pipeline. The deeper protein coexpression network analysis revealed …

Multivariate network analysis of fiber tract integrity in Alzheimer's disease

SJ Teipel, R Stahl, O Dietrich, SO Schoenberg… - Neuroimage, 2007 - Elsevier
… early in Alzheimer’s disease (AD). Studies using region of interest or voxel-based analysis
of … We applied a multivariate network analysis based on principal component analysis to …

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease

Q Zhang, C Ma, M Gearing, PG Wang, LS Chin… - Acta neuropathologica …, 2018 - Springer
network analysis uncovers AD-associated protein networknetwork analysis by using WGCNA,
a data-driven network … the proteome into a network of biologically meaningful modules of …

Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory

W De Haan, YAL Pijnenburg, RLM Strijers… - BMC neuroscience, 2009 - Springer
… in large-scale functional brain networks in patients with Alzheimer's disease (AD) and
frontotemporal lobar degeneration (FTLD) by means of graph theoretical analysis of resting-state …

Transcriptomic and network analysis highlight the association of diabetes at different stages of Alzheimer's disease

JA Santiago, V Bottero, JA Potashkin - Frontiers in Neuroscience, 2019 - frontiersin.org
… a transcriptomic and network analysis of gene expression datasets from MCI, AD, advanced
AD, and T2D patients to better understand the shared molecular networks disrupted through …