Neural network modeling of memory deterioration in Alzheimer's disease

D Horn, E Ruppin, M Usher, M Herrmann - Neural computation, 1993 - direct.mit.edu
… The clinical course of Alzheimer’s disease (AD) is generally … , we use a neural network model
to investigate how the interplay … Within the model we show that the deterioration of memory …

[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease

M Wang, A Li, M Sekiya, ND Beckmann, X Quan… - Neuron, 2021 - cell.com
… To identify the molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's
Disease (LOAD), we performed an integrative network analysis of multi-omics profiling of …

Alzheimer disease: modeling an Aβ-centered biological network

D Campion, C Pottier, G Nicolas, K Le Guennec… - Molecular …, 2016 - nature.com
network-based analyses are an attractive complement to classical approaches. In Alzheimer
disease (… /proteins involved in this biological network and classified them according to their …

Dynamic network modeling of gut microbiota during Alzheimer's disease progression in mice

Y Li, Y Chen, Y Fan, Y Chen, Y Chen - Gut Microbes, 2023 - Taylor & Francis
network modeling approach to neurological diseases or even broader clinical research
fields, which would facilitate the faster and more efficient development of disease interventions. …

Synapse loss and progress of Alzheimer's disease-A network model

G Kashyap, D Bapat, D Das, R Gowaikar… - Scientific Reports, 2019 - nature.com
… Based on this, a network model of neurons is developed, that explains the consequent loss
… from this model. We also show how the global efficiency of signal transmission in the network

Application of artificial neural network model in diagnosis of Alzheimer's disease

N Wang, J Chen, H Xiao, L Wu, H Jiang, Y Zhou - BMC neurology, 2019 - Springer
Alzheimer’s disease has become a public health crisis globally due to its increasing … The
purpose of this study was to establish an early warning model using artificial neural network (…

Challenges of integrative disease modeling in Alzheimer's disease

S Golriz Khatami, C Robinson, C Birkenbihl… - Frontiers in molecular …, 2020 - frontiersin.org
… Dementia-related diseases like Alzheimer's Disease (AD) have a tremendous social and
economic cost. A deeper understanding of its underlying pathophysiologies may provide an …

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease

AT McKenzie, S Moyon, M Wang, I Katsyv… - Molecular …, 2017 - Springer
… gene networks constructed from … networks using gene expression datasets generated from
mice with ablation of major gene expression nodes identified in our AD-dysregulated networks

[HTML][HTML] Biomarker modeling of Alzheimer's disease

CR Jack, DM Holtzman - Neuron, 2013 - cell.com
Models of the temporal evolution of AD biomarkers can take the form of plots of biomarker …
In this Review, we discuss several time-dependent models of AD that take into consideration …

Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex disease

P Hallock, MA Thomas - Omics: a journal of integrative biology, 2012 - liebertpub.com
diseases like Alzheimer's disease. We constructed a “Core” Alzheimer's disease protein
interaction network by … The Core network consisted of 775 nodes and 2,204 interactions. To our …