Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

B Bai, D Vanderwall, Y Li, X Wang, S Poudel… - Molecular …, 2021 - Springer
proteomics. Searching PubMed’s literature repository with terms “Alzheimer’s or Alzheimer
and “Proteomics or Proteome” … in 2020, although the AD proteomics field emerged at the turn …

Proteomics landscape of Alzheimer's disease

AP Jain, G Sathe - Proteomes, 2021 - mdpi.com
disease progression and therapeutic responses. Keeping this goal in mind several studies
using quantitative proteomics platform … (MS)-based proteomics studies on AD and discuss the …

The landscape of metabolic brain alterations in Alzheimer's disease

…, Alzheimer's Disease Metabolomics … - Alzheimer's & …, 2023 - Wiley Online Library
… from the Accelerating Medicine Partnership Program for Alzheimer's Disease (AMP-AD) …
in AD by integrating our metabolomic findings with additional proteomic data. (4) Identifying tau …

CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels

M Del Campo, CFW Peeters, ECB Johnson, L Vermunt… - Nature aging, 2022 - nature.com
… patients with mild cognitive impairment with Alzheimer’s pathological changes (MCI(Aβ+)), …
without Alzheimer’s pathological changes. Our first aim was to define new CSF proteomic

[PDF][PDF] Proteomics Landscape of Alzheimer's Disease. Proteomes 2021, 9, 13

AP Jain, G Sathe - 2021 - pdfs.semanticscholar.org
disease progression and therapeutic responses. Keeping this goal in mind several studies
using quantitative proteomics platform … (MS)-based proteomics studies on AD and discuss the …

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer's disease

L Ping, SR Kundinger, DM Duong, L Yin, M Gearing… - Scientific data, 2020 - nature.com
… from both total proteome and IMAC proteome. In the total proteome, 17% of peptides mapping
to Tau were phosphopeptides, while 74% of all Tau peptides in the IMAC proteome were …

[HTML][HTML] Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression

B Bai, X Wang, Y Li, PC Chen, K Yu, KK Dey… - Neuron, 2020 - cell.com
Alzheimer’s disease (AD) displays a long asymptomatic stage before dementia. We … 5xFAD
shows a proteomic signature similar to symptomatic AD but exhibits activation of autophagy …

In-depth site-specific analysis of N-glycoproteome in human cerebrospinal fluid and glycosylation landscape changes in Alzheimer's disease

Z Chen, Q Yu, Q Yu, J Johnson, R Shipman… - … & Cellular Proteomics, 2021 - ASBMB
… As accumulating evidence suggests that defects in glycosylation are involved in
Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic …

Glycoproteomics landscape of asymptomatic and symptomatic human Alzheimer's disease brain

S Suttapitugsakul, K Stavenhagen, S Donskaya… - … & Cellular Proteomics, 2022 - ASBMB
Molecular changes in the brain of individuals afflicted with Alzheimer's disease (AD) are an
intense area of study. Little is known about the role of protein abundance and …

Proteomic analysis of Alzheimer's disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatment

EB Dammer, A Shantaraman, L Ping… - Science translational …, 2024 - science.org
… Here, we characterized the proteomic landscape of … individuals using two different proteomic
technologies—tandem mass … CSF proteomics in autosomal dominant Alzheimer's disease