… role of early vascular dysfunction in the onset of LOAD/SAD. The “vascular hypothesis” for AD
… Alzheimer in 1906 revealed not only the presence of senile plaques but also the presence …

… Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer’s disease (AD), involving dysregulated cellular interactions. An intricate balance …

… Vascular dysfunction, including BBB breakdown, is increasingly recognized as contributory
to AD pathophysiology. In vivo BBB imaging in humans can inform regional brain changes in …

… In this review, we discuss several potential pathological pathways of vascular involvement …
the origin of the disease development. At neuroimaging, signs of vascular dysfunction such as …

… Vascular dysfunction is frequently observed in disorders associated … Alzheimer’s disease
(AD). Recent advances in neuroimaging and fluid biomarkers suggest that vascular dysfunction …

… to underlying vascular problems. Whether this vascular dysfunction actually causes AD or
merely contributes to the development of the disease or worsens the disease processes once …

… Endothelial dysfunction that was detected in patients with AD free of the diseases that
may influence the integrity of vascular endothelium in this study may be a result of the beta-…

… Vascular dysfunction can also influence the amyloidogenic pathway to diminish Aβ clearance
and increase Aβ production leading to elevated Aβ levels in the brain [1], [11]. Thus, the Aβ…

… Vascular dysfunction also includes a diminished brain capillary flow, causing multiple focal
… dysfunction. Here we present and discuss relevant findings on the contribution of vascular …

… Vascular dysfunction resulting in decreased cerebral blood flow, and abnormalities in the
blood brain barrier may also contribute to the Alzheimer's disease (… of vessel disease, vascular …