Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

R Apátiga-Pérez, LO Soto-Rojas… - … brain disease, 2022 - Springer
… angiopathy, CAA) is a major contributor to vascular dysfunction in AD. Vascular amyloid
deposits could be early events in AD due to dysfunction in the neurovascular unit (NVU) and the …

The vascular side of Alzheimer's disease

A Liesz - Science, 2019 - science.org
vascular dysfunction in living AD patients. However, none of these trials included vascular
dysfunction … Might vascular dysfunction indeed be an intermediate pathophysiological process …

Alzheimer's disease and endothelial dysfunction

G Bomboi, L Castello, F Cosentino, F Giubilei… - Neurological …, 2010 - Springer
… For instance, identification of vascular dysfunction may constitute a powerful predictor …
dysfunction at level of the neurovascular unit plays a role in the pathogenesis of Alzheimer disease

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

K Kisler, AR Nelson, A Montagne… - Nature Reviews …, 2017 - nature.com
vascular dysfunction in animal models, including amyloid-β-independent vascular changes,
amyloid-β-dependent vascular … Last, we emphasize Alzheimer disease vascular dysfunction, …

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer's disease

RD Bell, BV Zlokovic - Acta neuropathologica, 2009 - Springer
Vascular dysfunction has a critical role in Alzheimer’s disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

BV Zlokovic - Nature Reviews Neuroscience, 2011 - nature.com
… in Alzheimer's disease results from unsuccessful vascular repair … Does vascular dysfunction
cause neuronal dysfunction? In … vascular dysfunction is tightly linked to neuronal dysfunction. …

Alzheimer's disease, cerebrovascular dysfunction and the benefits of exercise: from vessels to neurons

C Lange-Asschenfeldt, G Kojda - Experimental gerontology, 2008 - Elsevier
… regarding the primary prevention of AD from a vascular point of view. First, we will point
out the mutual interconnection of vascular dysfunction and AD pathophysiology. We will then …

Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets

BV Zlokovic - Advanced drug delivery reviews, 2002 - Elsevier
… This review is focused on specific aspects of vascular dysfunction in AD related to …
dysfunction for Aβ is probably a late event in AD possibly resulting form disease-specific vascular

Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease

Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
dysfunction of the BBB is likely involved in the pathogenesis of several neurological diseases,
including Alzheimer’s disease (… Thus, current evidence suggests that BBB dysfunction may …

Neurovascular function in Alzheimer's disease patients and experimental models

N Nicolakakis, E Hamel - Journal of Cerebral Blood Flow & …, 2011 - journals.sagepub.com
… These findings challenged the view that soluble Aβ could initiate vascular dysfunction at
concentrations inhibiting neuronal function. It also suggested that vascular deficits may act as …