… But the enzyme NADPH oxidase has emerged as an important source of the ROS that are
responsible for vascular dysfunction in other conditions associated with vascular oxidative …

… Vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (…
cell extravasation, are considered biomarkers of vascular dysfunction and inflammation [60,64]. …

… on endothelial cells and cellular components of the BBB are promising approaches that can
provide strategies to mitigate vascular dysfunction and break the damage cycle during AD. …

… It is widely accepted that hypoperfusion and changes in capillary morphology are involved
in the etiopathogenesis of Alzheimer's disease (AD). This is difficult to reconcile with the …

… with an increased risk of Alzheimer’s disease (AD). Many of these studies indicate that
vascular risk factors can predict the clinical development of cognitive dysfunction and AD onset. …

… disease progression, neurovascular dysfunction, and amyloid-ß pathology. The studies
reviewed here have identified vascular-… avenues for the treatment of this devastating disease. …

… vascular disease24, gender25) could also lower the threshold concentration of Ab required
for cerebral vascular dysfunction. Vascular dementia is recognized as a neurodegenerative …

… NEUROVASCULAR DYSFUNCTION The influence of vascular dysfunction has been an …
favorable conditions for Aβ clearance counteracting Alzheimer's vascular dysfunction. …

… It is the opinion of the authors of this review, as well as a steadily increasing number of
investigators (8,19), that the vascular dysfunction may precede the neuronal damage and …

… This study provides multi-modal evidence that vascular dysfunction is significant in the
development of AD in APOE4 carriers. Both CAA and parenchymal amyloid pathologies are more …