… -associated genetic variants. We … genetic variants at multiple biophysical scales. Furthermore,
we highlight the clinical potential of mechanistically coupling genetic variants and disease …

… This strategy, followed by “fine mapping”—the positional cloning of candidate genes—was
used to identify genes and genetic variants contributing to AD risk. The first three genes …

Alzheimer disease (AD) is a complex neurodegenerative disease. Genetic and molecular
studies have confirmed that in the human brain, amyloid-β fibrils can induce, through the …

… Alzheimer disease (AD) is a remarkable example of genetic heterogeneity. Extremely rare
variants in the APP, PSEN1, or PSEN2 genes… by the SORL1 Alzheimer’s disease genetic risk …

… Late-onset Alzheimer disease (AD) is the most common cause of dementia … for genetics in
late-onset AD, with heritability estimates of 60% to 80%. Until recently, the only genetic variant …

… it has been estimated to account for less than half of the genetic contribution to AD risk.3
The possibility that genetic variation at the ACE locus may influence risk for AD is supported by …

… The search for functionally relevant genetic variants in risk loci detected in … to disease. Next,
we present accumulating evidence of rare variants contributing to risk of Alzheimer's disease…

… genes carrying a higher burden of rare, protein-truncating and missense predicted damaging
variants in Alzheimer disease (… coding variants has been demonstrated at the gene level by …

… Association of genetic variants with risk of clinical PCA or posterior AD only or combined …
An additive model was tested for all genetic variants. A recessive model was also tested for …

… resilience metrics were genetically correlated with … genetically correlated with clinical
Alzheimer’s disease (P-values > 0.42) nor associated with APOE (P-values > 0.13). In single variant …