… The exact mechanism by which blood exchange reduces amyloid pathology and improves
… in amyloid deposition by blood exchange was even higher when we estimated the amyloid …

… Similar, serum amyloid P (SAP) component can be removed from human amyloid deposits in
… The dynamics of Aβ transport exchanges between brain and blood, and blood and brain, is …

… Parenchymal β-amyloid deposition is dependent on the … of zinc to vascular β-amyloid
deposition remains unclear. Here, … ZnT3 was not detected in the cerebral vessel walls or in blood …

… We have also shown that performing whole-blood exchanges reduced amyloid deposits
in the brain and improved the cognitive performance of a mouse model of AD (Tg2576) [23]. …

… To evaluate whether the induction of amyloid deposition can be also observed under more
natural conditions, we studied the pathological transmission through blood transfusion, a …

The accumulation of amyloid-ß protein (Aß) and tau in the brain is a major pathological change
related to Alzheimer’s disease. We have continued to develop Extracorporeal Blood Aß …

… amyloid-β (Aβ) from the brain, Aβ peptides produced mainly in neurons are degraded by
peptidases, flow out of the brain parenchyma into the blood … Amyloid deposits in the basement …

… In this study, we tested the hypothesis that circulating Aβ may contribute to the development
of parenchymal amyloidosis and cerebral amyloid angiopathy (CAA) in primates. The …

… Although amyloid deposits are often described as inert, there is evidence that … When
amyloid is present, 123 I- SAP from the blood exchanges through a dynamic equilibrium with the …

… ,6b,7 whereas the aggregated amyloid deposits contain regular fibrillar structures that can
be … tests for AD patients who, via plasma exchange, had part of their HSA pool replaced with …