… on the metallo-β-lactamases, especially the New Delhi metallo-βlactamase [57], … β-lactam
antibiotics. Particularly, we shall focus on the general structure features, antibiotic recognition …

… Metallo- or class B β-lactamases (mβls) present a challenge of increasing significance to
the clinical effectiveness of β-lactam antibiotics. Since their initial discovery in clinically …

… -requiring (metallo) β-lactamases, have been shown to hydrolyze most β-lactam antibiotics,
… against the catalog of structurally diverse β-lactam antibiotic substrates presently available. …

Metallo-β-lactamases are broad-spectrum zinc enzymes, able to inactivate most clinically
useful β-lactam antibiotics. Their structural and functional diversity has thus far limited the …

… antibiotics are recognized by dizinc-containing metallo-β-… -resolution structural data for
any metallo-β-lactamase reported to … of novel inhibitors of NDM-1 and other metallo-β-lactamases. …

… β-Lactam antibiotics are used for the treatment of both Gram-negative and Gram-positive …
are the most commonly prescribed antibiotics (4, 5). β-Lactam antibiotics act as inhibitors of cell …

… β-lactam antibiotics that are not recognized by β-lactamases; (ii) coadministration of β-lactam
antibiotics with β-… Recently, a novel resistance factor called the New Delhi metallo-β-…

… This study showed that the importance of N 233 depends on the antibiotics tested for NDM-1,
consistent with earlier findings for IMP-1 (28). The dramatic loss of activity by K 224 A to …

… Some metal-based antibiotics such as bleomycin, streptonigrin, and bactracin have gained
recognition and are more effective than pure drugs 2. Cobalt complex with histidine ligand …

… Multiple resistance mechanisms against β-lactam antibiotics involve Zn(II) ions as essential
… mechanism towards β-lactam antibiotics involving Zn(II) ions is the expression of metallo-β-…