… Integrons are genetic elements of variable length that contain a 5′ conserved integrase
gene (int), gene cassettes with other antibiotic resistance genes, and an integration site for the …

… The β-lactamases confer significant antibiotic resistance to their bacterial hosts by hydrolysis
of the amide bond of the four-membered β-lactam ring. These enzymes are especially …

… classes of antibiotics, could … of resistance to the future generation of β-lactams by bacteria
is inevitable and therefore much care must be taken in the way we use β-lactam antibiotics in …

… .1, 2 Three of six dangerous pathogens are antibiotic-resistant Gram-negative pathogens. …
resistance is that severe clinical problems arise from the emergence of antibiotic resistance …

… resistance mechanisms include the development of novel β-lactamase-stable β-lactams,
β-lactamase inhibitors to be employed with existing β-lactams, β-lactam compounds that bind …

Production of extended-spectrum β-lactamases (ESBLs) is the principal mechanism of
resistance to oxyimino-cephalosporins evolved by members of the family Enterobacteriaceae. …

… β-lactam antibiotic such as meropenem as we show here, resistance can be overcome and
antibiotic … AMA (or semi-) is therefore an excellent lead for an antibiotic adjuvant co-therapy to …

… the effect of β-lactamases. This review discussed the mechanism of β-lactam antibiotic
activity, the mechanisms of β-lactam antibiotic resistance and how to overcome the effect of the β-…

… The most prevalent resistance mechanism is the expression of enzymes tailored to
hydrolyze these antibiotics, namely, β-lactamases. Most β-lactamases possess an essential Ser …

… Antibiotic resistance is a problem of deep scientific concern both in hospital and community
settings. Rapid detection in clinical laboratories is essential for the judicious recognition of …