C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
… study, we evaluate neutralization of a series of mutatedspike … neutralization of the B.1.1.7 spike pseudotype and individual … Spike-specific monoclonal antibodyneutralization is reduced …
… , it is important to anticipate patterns of antibody resistance that might arise. Here, we … -2 S mutants that escape antibodyneutralization. We show that mutations conferring resistance to …
… Reduced susceptibility to neutralizingantibodies from convalescent patients and vaccine … of the L452R mutation on antibody binding, we performed neutralizingantibody assays. We …
Q Wang, SB Ye, ZJ Zhou, AL Song… - Journal of Medical …, 2023 - Wiley Online Library
… However, the rapid mutations of SARS-CoV-2 spike (S) protein may reduce the protective … of neutralizingantibodies targeting S. In this study, we screened prevalent S mutations and …
… We next evaluated whether individual mutants could escape neutralization by the other inhibitory mAbs in the panel. We tested the 29 identified escape mutants for neutralization by ten …
… induced by previous infection or vaccination through mutations in the spike protein, … mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized …
… Thus, understanding the impact of these various mutations on the neutralization capacity of antibodies elicited by current vaccine formulations or natural exposure to WT SARS-CoV-2 is …
… The variant carries three mutations in the spike protein, including … N501Y mutation common to variants B.1.1.7, B.1.351, and P.1. … antibodyneutralization warrants further investigation. …
SA Kemp, DA Collier, R Datir, IATM Ferreira, S Gayed… - MedRxiv, 2020 - ncbi.nlm.nih.gov
… Mutations in the receptor binding domain (RBD) of Spike are of … antibodies and therapeutic monoclonal antibodies. … in a global change in neutralization sensitivity we tested neutralising …