[HTML][HTML] Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - Cell host & …, 2021 - cell.com
… We next evaluated whether individual mutants could escape neutralization by the other
inhibitory mAbs in the panel. We tested the 29 identified escape mutants for neutralization by ten …

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
… study, we evaluate neutralization of a series of mutated spikeneutralization of the B.1.1.7
spike pseudotype and individual … Spike-specific monoclonal antibody neutralization is reduced …

[HTML][HTML] Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Y Weisblum, F Schmidt, F Zhang, J DaSilva, D Poston… - elife, 2020 - elifesciences.org
… , it is important to anticipate patterns of antibody resistance that might arise. Here, we … -2 S
mutants that escape antibody neutralization. We show that mutations conferring resistance to …

[HTML][HTML] Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation

X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - MedRxiv, 2021 - ncbi.nlm.nih.gov
… Reduced susceptibility to neutralizing antibodies from convalescent patients and vaccine …
of the L452R mutation on antibody binding, we performed neutralizing antibody assays. We …

Key mutations in the spike protein of SARS‐CoV‐2 affecting neutralization resistance and viral internalization

Q Wang, SB Ye, ZJ Zhou, AL Song… - Journal of Medical …, 2023 - Wiley Online Library
… However, the rapid mutations of SARS-CoV-2 spike (S) protein may reduce the protective …
of neutralizing antibodies targeting S. In this study, we screened prevalent S mutations and …

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z Liu, LA VanBlargan, LM Bloyet, PW Rothlauf… - BioRxiv, 2020 - biorxiv.org
… We next evaluated whether individual mutants could escape neutralization by the other
inhibitory mAbs in the panel. We tested the 29 identified escape mutants for neutralization by ten …

[HTML][HTML] SARS-CoV-2 spike E484K mutation reduces antibody neutralisation

S Jangra, C Ye, R Rathnasinghe, D Stadlbauer… - The Lancet …, 2021 - thelancet.com
… induced by previous infection or vaccination through mutations in the spike protein, …
mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized

Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

S Changrob, Y Fu, JJ Guthmiller, PJ Halfmann, L Li… - Mbio, 2021 - Am Soc Microbiol
… Thus, understanding the impact of these various mutations on the neutralization capacity of
antibodies elicited by current vaccine formulations or natural exposure to WT SARS-CoV-2 is …

[HTML][HTML] Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - Cell, 2021 - cell.com
… The variant carries three mutations in the spike protein, including … N501Y mutation common
to variants B.1.1.7, B.1.351, and P.1. … antibody neutralization warrants further investigation. …

[HTML][HTML] Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation

SA Kemp, DA Collier, R Datir, IATM Ferreira, S Gayed… - MedRxiv, 2020 - ncbi.nlm.nih.gov
Mutations in the receptor binding domain (RBD) of Spike are of … antibodies and therapeutic
monoclonal antibodies. … in a global change in neutralization sensitivity we tested neutralising …