… to the traditional antibody Fc-effector functions (ie, antibody-… Fc-mediated effector functions
of neutralizing antibodies may … the role of antibody potency, effector function, and antibody …

… antibody effector functions that exist and contemplate how an increased knowledge of these
functions … Thus, despite the functional potency of IgG3, it has the shortest half-life among all …

… Indeed, binding affinity is a principal driver of potency for some highly successful therapeutic
antibodies that neutralize cytokines, growth factors or complement factors. Binding of the …

… Neutralizing antibodies (red) are also able to mediate Fc effector functions, as are non-…
’ encourage the perception that only antibodies that do not neutralize can mediate potent Fc …

… The performance of an antibody in antibody-… ” the function of the cell to which it is targeted.
Studies using matched sets of antibodies [ l , 21 have indicated that IgGl is the most potent …

… Therefore, mAb glycosylation was assessed to determine if glycan structures were more
highly predictive of potent antibody effector function. Increased galactosylation correlated with …

… counteracts the biologic process can be optimized for selectivity and potency by modifying
the sequence of the antibody-based molecule to enhance or abrogate its interaction with the …

… modulate effector function, and where appropriate, provide examples of clinical studies where
Fc engineered antibodies have been employed. … Potent antibody therapeutics by design …

… cells into mice or establishing human FcγRIII transgenic mice, the actual potency of
engineered antibodies in the clinic is still difficult to foresee by using these models with limited …

… Using V2-specific antibodies previously isolated from donor CAP256, we showed that the
IgG3 constant region improved both Fc effector function and neutralization potency. This effect …