… IgGA exhibited highly potent CDC, resulting in tumor cell lysis at higher antibody concentrations
(up to 70%) and detectable killing even at a very low concentration (0.625 μg/ml, up to 18…

… profiles, through the selection of more potent antibody … antibodies with highly coordinated
Fc-mediated effector … A244 responses within our preliminary Fc-effector function assays (fig. S2)…

… monkey IgE effector cells. This is likely to affect the potency of IgE effector functions in these
two … Although differences in responses to antibody administration cannot be completely …

… , marking a functional humoral immune signature of protection against RSV. Furthermore,
Fc-modified monoclonal antibodies able to selectively recruit effector functions demonstrated …

… through a variety of antibody-mediated innate effector cell mechanisms. The role of … effector
cell functions. Mounting evidence suggests that serum IgA induces potent effector functions …

… , antibody engineering technologies are constantly advancing to enable further tuning of the
effector function … Improving affinity can improve the potency, pharmacokinetics, and reduce …

… of these antibodies to elicit Fc-dependent effector functions has … However, the way in which
Fc-dependent effector functions … of potent ADCC induction by nonneutralizing antibodies is …

… Given the lack of a requirement for conventional effector functions with B1 in our model
system, we explored whether apoptosis might explain the potent immunotherapy. Therefore, we …

… N-linked glycosylation appended to the IgG Fc region is critical for the binding of Fc to Fc
ligands (FcγRs and C1q) and for determining the potency of effector functions (ADCC and CDC)…

… site for an activating trigger molecule on effector cells. Potent trigger molecules are CD3 on
T … Apart from the more favorable cytotoxic properties, bispecific antibodies offer the unique …