[HTML][HTML] Polyfunctional HIV-specific antibody responses are associated with spontaneous HIV control

ME Ackerman, A Mikhailova, EP Brown… - PLoS …, 2016 - journals.plos.org
… an array of extra-neutralizing antibody effector functions across HIV-infected populations with
… the high potential relevance of maximizing antibody effector function breadth and potency. …

Antibody effector functions in malaria and other parasitic diseases: a few needles and many haystacks

EH Aitken, S Mahanty… - Immunology and Cell …, 2020 - Wiley Online Library
antibody effector functions relevant to these parasites. Studies that use malaria protein
arrays to profile antibody … are unclear as potent human monoclonal antibodies against the N …

Fc engineering: design, expression, and functional characterization of antibody variants with improved effector function

S Derer, C Kellner, S Berger, T Valerius… - Antibody Engineering …, 2012 - Springer
antibody therapy. Since human IgG1 is the most commonly used antibody isotype in cancer
therapy, antibody … the importance of Fc glycosylation on IgG1 antibody effector function (7–9). …

[HTML][HTML] Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk

SD Neidich, Y Fong, SS Li, DE Geraghty… - The Journal of …, 2019 - Am Soc Clin Investig
… of the antibody correlate of HIV-1 risk, we examined antigen-specific antibody recruitment of
Fcγ receptors (FcγRs), antibody-… , antibody-dependent monocyte phagocytosis and antibody

[HTML][HTML] A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

A Tauzin, M Nayrac, M Benlarbi, SY Gong, R Gasser… - Cell host & …, 2021 - cell.com
… binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4 +
antibody immunity. Our results highlight the potential role of Fc-mediated effector functions

Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers

JI Lai, AF Licht, AS Dugast, T Suscovich, I Choi… - Journal of …, 2014 - Am Soc Microbiol
… Significantly, Fc-mediated antibody effector functions have likewise been associated with …
, we compared the effector function and biophysical features of HIV-specific antibodies in a …

[HTML][HTML] Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2

SR Mackin, P Desai, BM Whitener, CE Karl, M Liu… - Nature …, 2023 - nature.com
effector functions to antibody protection against SARS-CoV-2 infection, we profiled
vaccine-induced antibodies … We measured the binding of antibodies to several spike proteins …

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

CH Lee, G Romain, W Yan, M Watanabe… - Nature …, 2017 - nature.com
… The enhanced CDC killing potency of ofatumumab is due to its binding to a membrane-…
Overwhelmingly, the effector function of therapeutic antibodies is thought to be dominated by …

[HTML][HTML] Anti-HIV-1 Nanobody-IgG1 constructs with improved neutralization potency and the ability to mediate fc effector functions

AI Schriek, MM van Haaren, M Poniman… - Frontiers in …, 2022 - frontiersin.org
potency compared to the J3-bihead and restored Fc-mediated effector functions such as
antibody-… breadth and potency and their ability to induce effector functions these nanobody-IgG1 …

[HTML][HTML] … -Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions

V Bobkov, AM Zarca, A Van Hout, M Arimont… - Biochemical …, 2018 - Elsevier
effector functions. In order to further increase their binding affinities and to restore
antibody-mediated effector functions, … potencies of nanobodies and to re-introduce …