[HTML][HTML] The antigenic anatomy of SARS-CoV-2 receptor binding domain

W Dejnirattisai, D Zhou, HM Ginn, HME Duyvesteyn… - Cell, 2021 - cell.com
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

A Mittal, A Khattri, V Verma - PLoS Pathogens, 2022 - journals.plos.org
… To understand the antigenic anatomy of the SARS-CoV-2 spike protein, and the molecular
mechanism of SARS-CoV-2 neutralization mediated by numerous mAbs, several laboratories …

Factors that influence the reported sensitivity of rapid antigen testing for SARS-CoV-2

V Parvu, DS Gary, J Mann, YC Lin, D Mills… - Frontiers in …, 2021 - frontiersin.org
… -based lateral flow testing (RALFT) to RT-qPCR for SARS-CoV-2. Generally, the … SARS-CoV-2
antigen test sensitivity. Other design factors, such as specimen storage and anatomical

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

C Liu, D Zhou, R Nutalai, HME Duyvesteyn… - Cell Host & Microbe, 2022 - cell.com
… 2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter
the antigenic structure of … The antigenic anatomy of SARS-CoV-2 receptor binding domain. …

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson… - Science, 2021 - science.org
… acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are … acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) … , and consequences of antigenic drift in SARS-CoV-2. In the …

An antigenic space framework for understanding antibody escape of SARS-CoV-2 variants

NL Miller, T Clark, R Raman, R Sasisekharan - Viruses, 2021 - mdpi.com
… The evolution of mutations in SARS-CoV-2 at antigenic sites … to anticipate future antigenic
mutations as the virus navigates … anti-SARS-CoV-2 antibodies to map an antigenic space that …

SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

A Grifoni, J Sidney, R Vita, B Peters, S Crotty… - Cell host & …, 2021 - cell.com
… We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant
… size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human …

Structure of a vaccine-induced, germline-encoded human antibody defines a neutralizing epitope on the SARS-CoV-2 spike N-terminal domain

CG Altomare, DC Adelsberg, JM Carreno, IA Sapse… - Mbio, 2022 - Am Soc Microbiol
… Our data, however, show that mRNA SARS-CoV-2 vaccination induced antibody
responses to this particular epitope, indicating that under physiological processes of antigen

Anatomy of Omicron BA. 1 and BA. 2 neutralizing antibodies in COVID-19 mRNA vaccinees

E Andreano, I Paciello, S Marchese, L Donnici… - Nature …, 2022 - nature.com
… the appearance of several antigenic variants which escaped … , the functional and genetic
anatomy of nAbs elicited in naïve … for the first time the anatomy of BA.1, BA.2, and SARS-CoV-1 …

Antibody and B cell responses to SARS-CoV-2 infection and vaccination

K Röltgen, SD Boyd - Cell host & microbe, 2021 - cell.com
… from prior exposure to other HCoVs recognize SARS-CoV-2 antigens. Anti-HCoV antibodies
are also boosted by SARS-CoV-2 infection, particularly during severe COVID-19 illness ( …