Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH …

Y Kitamura, T Kosaka, JI Kakimura, Y Matsuoka… - Molecular …, 1998 - ASPET
Treatment of human neuroblastoma SH-SY5Y cells with 1 mm1-methyl-4-phenylpyridinium (MPP
+ ) for 3 days induced production of reactive oxygen species (ROS), followed by …

The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

W Maruyama, T Takahashi, M Youdim… - Journal of neural …, 2002 - Springer
… This paper presents the data that the anti-parkinson drug, rasagiline and its (S)-enantiomer
are some of the most potent neuroprotective reagents so far studied using SH-SY5Y cells. …

MPP+ increases α-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

C Gómez-Santos, I Ferrer, J Reiriz, F Viñals… - Brain research, 2002 - Elsevier
… -human primates, used as animal models of parkinsonism. Here we describe an increase in
α-synuclein expression in a human neuroblastoma … by the antiparkinsonian drugs, talipexole …

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB …

W Maruyama, A Nitta, M Shamoto-Nagai… - Neurochemistry …, 2004 - Elsevier
… , rasagiline, an anti-Parkinson drug, was found to increase the protein and mRNA levels
of glial cell line-derived neurotrophic factor (GDNF) in human neuroblastoma SH-SY5Y cells, …

Dopamine induces autophagic cell death and α‐synuclein increase in human neuroblastoma SH‐SY5Y cells

C Gómez‐Santos, I Ferrer, AF Santidrián… - Journal of …, 2003 - Wiley Online Library
… We report here that human neuroblastoma SH-SY5Y cells treated with DA undergo
autophagy before death. Autophagy is a route for the sequestration of cytoplasm to a lytic …

An Endogenous Dopaminergic Neurotoxin, N‐Methyl‐(R)‐Salsolinol, Induces DNA Damage in Human Dopaminergic Neuroblastoma SH‐SY5Y Cells

W Maruyama, M Naoi, T Kasamatsu… - Journal of …, 1997 - Wiley Online Library
… This article reports that NM(R)SaI induces DNA damage in human dopaminergic neuroblastoma
SHSY5Y cells. To assess DNA damage, a single-cell gel electrophoresis (comet) assay …

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

H Jiang, Y Ren, J Zhao, J Feng - Human molecular genetics, 2004 - academic.oup.com
… Here, we provide evidence that parkin protected human DA neuroblastoma cells by decreasing
the production of ROS and the activation of apoptotic pathways emanated from JNK. As …

Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells

P Gassó, S Mas, O Molina, M Bernardo… - Progress in Neuro …, 2012 - Elsevier
… SK-N-SH human neuroblastoma cells were purchased from the American Type Cell Culture
(ATCC, Manassas, VA, USA) and were cultured in MEM supplemented with 10% FBS, 2 mM …

Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro

N Giladi, M Sutton, B Lo, S Przedborski, S Fahn… - Toxicology in vitro, 1993 - Elsevier
… , we made use of these very well characterized human neuroblastomadrugs on the viability
of human neuroblastoma cells. We now report that several non-specific antimuscarinic drugs

β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP+ Toxicity in Human Neuroblastoma SH-SY5Y Cells

J Fernandez-Abascal, M Ripullone, A Valeri… - International Journal of …, 2018 - mdpi.com
… We have studied the inducibility of CYP isozymes in human neuroblastoma SH-SY5Y cells,
treated with β-naphtoflavone (β-NF) or ethanol (EtOH) as inducers, by qRT-PCR, Western …