… his family consists of three structurally related IFN-λ subtypes called IFN-λ1 (IL-29), IFN-λ2
(IL-28A), and IFN-λ3 (IL-28B). In this study we investigate the antiviral activities of IFN-λ1, λ2, …

… Finally, we show that recombinant IFN-λ exhibits antiviral activity against the DNA virus …
(LCMV), and that IFN-λ treatment enhances HSV-induced expression of IFN-γ, a cytokine known …

… Interferons (IFNs) are essential components of the antiviral defense system of vertebrates. In
… for type III IFN (lambda interferon [IFN-λ]) are found mainly on epithelial cells, and IFN-λ was …

… ‐10R2, as do the other members of the type III interferon family. Furthermore, we show that
IFNλ4 has antiviral activity in human hepatocytes against HCV and in primary human airway …

… a similar set of IFN-stimulated genes (ISGs). To examine the antiviral effects of the new type
IFNs against West Nile virus (WNV), we compared the antiviral effects of IFN-α and IFN-λ on …

… activity of the IFN-λ analogs, we measured their antiviral potency and compared it with that of
IFN-α2a and the natural IFN… Potency determination based on ISRE-driven luciferase activity …

… We showed that IFN-l1 or IFN-l3 had a better antiviral activity against HIV as compared
with IFN-l2 in treatment groups both before and after virus infection. The different antiviral …

… biological activities as IFN-α/β, including antiviral activity, but … IFN-λ was reported to induce
in vitro marked antiviral activity … Therefore we examined the IFN-λ1 induced antiviral activity …

… The antiviral activity of recombinant human IFN-lambda … antiviral activity against SARS-CoV-2
virus in vitro. In the tests with and without preincubation, IFNλ-1 exhibited significant activity…

… antiviral protection and development of adaptive immune responses in vivo. This was addressed
here by cloning murine IFN… IFN-λ cDNAs, we demonstrated potent antiviral activity of IFN…