SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
… effective antiviral therapy for COVID-19 is … antiviral therapies for COVID-19, including
research spanning preclinical and clinical drug development efforts, with an emphasis on antiviral

An update on antiviral therapy against SARS-CoV-2: how far have we come?

O Indari, S Jakhmola, E Manivannan… - Frontiers in …, 2021 - frontiersin.org
… and in vivo antiviral activity against SARS-CoV, MERS-CoV and SARS-CoV-2. Lopinavir/…
, were examined for COVID-19 as they were found to be effective in earlier CoV outbreaks. …

Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response

A Goyal, EF Cardozo-Ojeda, JT Schiffer - Science advances, 2020 - science.org
… We simulated antiviral therapies on top of our natural history model to shed light on the
possible impact of the timing and potency of antiviral therapies on outcomes. While accurate …

Potential role of peptide-based antiviral therapy against SARS-CoV-2 infection

BK Maiti - ACS pharmacology & translational science, 2020 - ACS Publications
coronavirus 2 (SARS-CoV-2) infectious disease (COVID-19) … requirement of suitable antiviral
agent/therapy to control this … of SARS-CoV-2 infection is the crosstalk between the SARS-…

SARS-CoV-2 RNA polymerase as target for antiviral therapy

L Buonaguro, M Tagliamonte, ML Tornesello… - Journal of Translational …, 2020 - Springer
antiviral drugs as treatment of SARS-CoV-2. This can accelerate the containment of the
SARS-CoV-2SARS-CoV-2 is a new human coronavirus identified in patients with acute …

Antiviral therapeutic approaches for SARS-CoV-2 infection: a systematic review

V Gil Martinez, A Avedillo Salas, S Santander Ballestin - Pharmaceuticals, 2021 - mdpi.com
SARS and MERS, have been used in patients with COVID-19. … of five antivirals applied to
patients with COVID-19, that have … studies or in studies on SARS-CoV and MERS.; An intensive …

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

X Xiao, C Wang, D Chang, Y Wang, X Dong… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 virus was isolated from the respiratory samples of patients … SARS-CoV-2 virus
was propagated in Vero cells and used in this study. All experiments with SARS-CoV-2 virus

Antiviral activities of type I interferons to SARS-CoV-2 infection

E Mantlo, N Bukreyeva, J Maruyama, S Paessler… - Antiviral research, 2020 - Elsevier
… identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of
SARS-CoV-2 … These results suggest that SARS-CoV-2 is more sensitive than many other human …

Impact of early SARS-CoV-2 antiviral therapy on disease progression

A De Vito, A Colpani, L Saderi, M Puci, B Zauli, V Fiore… - Viruses, 2022 - mdpi.com
… Our study showed that early SARS-CoV-2 antiviral therapy reduces the risk of disease
progression and, consequently, hospitalisation and death. However, prospective studies with a …

Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity

Z Shen, K Ratia, L Cooper, D Kong, H Lee… - Journal of medicinal …, 2021 - ACS Publications
… potent inhibitors with SARS-CoV-2 PLpro. In contrast to the identical active sites, there are
differences in amino acids proximal to the BL2 loop between SARS and SARS-CoV-2 PLpro; …