Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro

TK Kerppola, D Luk, T Curran - Molecular and Cellular Biology, 1993 - Taylor & Francis
… These results indicate that the differential inhibition of Fos-Jun heterodimer DNA binding by
… the distinct effects of the GR on transcription in cells containing different AP-1 complexes. …

Differential inhibition of UVB‐induced AP1 and NF‐κB transactivation by components of the jun bZIP domain

S Cooper, J Ranger‐Moore… - … in cooperation with the …, 2005 - Wiley Online Library
inhibited UVB‐induced NF‐κB transactivation but not AP1 … protein was able to inhibit
transactivation mediated by both … inhibit two significant UVB‐induced molecular targets AP1

AP-1 function and regulation

M Karin, Z Liu, E Zandi - Current opinion in cell biology, 1997 - Elsevier
inhibited by nuclear receptors, AP-1 activity is also inhibited by other proteins. The transcriptional
activity ofTPA-induced AP-1 (c-Jun-c-Fos) and also of NF-~rB is inhibited by … differential

Differential Inhibition of Glial K+ Currents by 4-AP

A Bordey, H Sontheimer - Journal of neurophysiology, 1999 - journals.physiology.org
… was revealed in our study through its differential sensitivity to 4-AP. Indeed, the key finding
… to 4-AP, each showing a distinctly different sensitivity for current inhibition by 4-AP. K IS was …

Differential inhibition of UV-induced activation of NFκ B and AP-1 by extracts from black raspberries, strawberries, and blueberries

C Huang, D Zhang, J Li, Q Tong, GD Stoner - HNUC, 2007 - Taylor & Francis
… Thus, we hypothesize that the differential inhibitory effects of black raspberries, strawberries,
and blueberries on UV-induced activation of NFκ B may be related to differences in their …

Identification of Two Forms of TNF Tolerance in Human Monocytes: Differential Inhibition of NF-κB/AP-1–and PP1-Associated Signaling

J Günther, N Vogt, K Hampel, R Bikker… - The Journal of …, 2014 - journals.aai.org
The molecular basis of TNF tolerance is poorly understood. In human monocytes we
detected two forms of TNF refractoriness, as follows: absolute tolerance was selective, dose …

Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites

K Paech, P Webb, GGJM Kuiper, S Nilsson… - Science, 1997 - science.org
inhibited ERβ-dependent transcription from an AP1 site (Fig. 5). No induction was seen
with cells that were not transfected with the ERβ expression plasmid, indicating that the …

Small molecule inhibitors targeting activator protein 1 (AP-1) miniperspective

N Ye, Y Ding, C Wild, Q Shen… - Journal of medicinal …, 2014 - ACS Publications
AP-1 biology and function, as well as the identification of small molecules modulating AP-1
and efficacious AP-1 inhibitors as a viable therapeutic strategy for human diseases. …

NF-κB and AP-1 connection: mechanism of NF-κB-dependent regulation of AP-1 activity

S Fujioka, J Niu, C Schmidt, GM Sclabas… - … and cellular biology, 2004 - Am Soc Microbiol
… Moreover, the differential binding of AP-1 and NF-κB to the interleukin-8 (IL-8) promoter …
To elucidate the mechanism underlying the inhibition of AP-1 activation by the IκBαM-mediated …

AP-1: a double-edged sword in tumorigenesis

R Eferl, EF Wagner - Nature Reviews Cancer, 2003 - nature.com
… , oncogenic AP-1 can antagonize apoptosis in liver tumours 9 . The differential activity of
AP-1 in … This approach would not only inhibit oncogenic AP-1 activity, but might also actively …