… of AP-1 to determination of cell fates critically depends on the relative abundance of AP-1
subunits, the composition of AP-1 … Therefore, AP-1-mediated regulation of processes such as …

… , signal transduction pathways and critical AP-1 members regulating the mammalian … on
AP-1 activity. Here we review our current knowledge on the function of AP-1 subunits and AP-1 …

… ) subunits that bind to a common DNA site, the AP-l-binding site. As the complexity of our
knowledge of AP-1 … deficient in specific AP-1 components. Such studies suggest that different …

… binding profiles and associated regulatory activity of five AP-1 subunits (JUN, JUNB, JUND,
… tag each AP-1 subunit, we were able to determine the genomic binding of each subunit at its …

… , only AP-1 physically associates with clathrin (33,34). Surprisingly, deletion of genes
encoding the four AP-1 subunits, or deletion of genes encoding all AP complex large subunits, …

… of AP-1 subunits soon after wounding in these reports and a loss of AP-1 subunits in our …
to different species (the expression pattern of AP-1 subunits in rodent skin is different to that in …

… These results are even more striking in the context of the expected molecular redundancy:
in most of the cases discussed above, inactivation of even a single AP-1 subunit results in …

… a gene-trap screen and identified the medium subunit (µ1) of the clathrin adaptor AP-1 as a
top hit. In µ1 … Our fourth hit was the AP-1 μ1 subunit. The AP complexes always operate as …

… AP-1 adaptor complex is involved in the assembly of clathrin-coated vesicles originating from
thetrans-Golgi network (TGN). The β1 subunit of AP-1 … γ subunit of human and mouse AP-1 …

… The μ1A knockout in mouse leads to the absence of both AP-1 complexes expressed in
brain, AP-1/σ1A and AP-1/σ1B. These embryos show most severe defects in brain development. …