… To investigate mechanisms of endogenous APOBEC3 mutagenesis, we deleted
APOBEC3A and APOBEC3B from a panel of cancer cell lines that acquire APOBEC3-associated …

… mutation types (C > A, C > G, C > T). b, (1) APOBEC3 mutagenesis is speculated to drive
cancer cell evolution and associated phenotypes, including tumor heterogeneity, therapeutic …

… In humans, APOBEC-generated genetic heterogeneity in tumor cells … cancer mutagenesis
and impact on disease and the biological processes that influence APOBEC mutagenic …

… APOBEC3-mediated mutagenesis impacts tumor evolution through both mutagenic and
non-mutagenic … The causes and clinical implications of APOBEC3-mediated mutagenesis are …

… -coordinated mutation clusters in yeast was increased following exposure of cells to the … In
this study, we investigated the genomic correlates of APOBEC3 mutagenesis in breast cancer. …

… We propose that APOBEC3-mediated mutagenesis can function as a helpful predictive …
several standard-of-care breast cancer treatment plans and may be a novel target for treatment. …

… in cancer mutagenesis and inspired experiments to directly test an APOBEC mutator …
suggested upregulation of at least one APOBEC3 in several cancers [19]. Third, precedents …

… source of DNA injury and mutation in cancer, which adds to the … exome-wide mutation data
files in The Cancer Genome Atlas … -like (APOBEC) cytidine deaminase mutagenesis patterns …

… based on modulating APOBEC3 activities in cancer 21–28 and to … , mutagenic APOBEC3
behavior. Here, by CRISPR-Cas9 deleting the candidate APOBEC3 mutators from cancer cell …

… APOBEC3 mutation signature evident in tumor DNA sequences. The bulk of evidence favors
two enzymes, APOBEC3A (A3A) and APOBEC3B (A3B), though to wildly different degrees …