… Increased arginase can also provide ornithine for synthesis of polyamines via ornithine …
that elevated arginase activity is involved in Ang II-induced arterial thickening, fibrosis, and …

… arginase promotes aberrant vascular remodeling in arterial injury… Arginase II drives arterial
thickening in PAH by stimulating … artery SMCs with IL-13 induces the expression of arginase II …

… promote vascular fibrosis and thickening, resulting in arterial stiffening. Arterial stiffening, an
… The importance of arginase in the regulation of vascular functions has become evident in a …

… The central aorta dilates with age (52), while the arterial wall thickness increases even in
the absence of atherosclerotic disease (64) mainly as a result of intimal thickening (86). …

… arginase expression/activity contribute to vascular endothelial cell (EC) dysfunction. Here, we
examined the roles of the two arginase isoforms, arginase I … coronary arteries with arginase …

… of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate
that arginase … improves endothelial function and arterial compliance in aging vasculature. …

… arginase expression in endothelial cells and its role in modulating NOS activity, both
biochemically and functionally. With advancing age, expression and function of arginase … arginase …

… , arginase-induced increases in polyamines and proline production can lead to thickening, …
expression and activity have also been implicated in pulmonary arterial hypertension (PAH)…

… In this review article, we will mainly discuss the role and mechanisms of the enzyme arginase
in … For example, eNOS expression in atherosclerotic arteries and arteries from diabetes …

… function of the arginase–ornithine pathway can be damaging in other contexts. For example,
arginase… of polyamines and proline can lead to thickened, fibrotic, and stiff blood vessels …