… demonstrate that arginase 1 expression in vascular endothelial cells plays an integral role
in the development of vascular endothelial dysfunction, vascular fibrosis, and stiffening and …

… to vascular cell proliferation and collagen formation, respectively. We hypothesized that
elevated arginase activity is involved in Ang II-induced arterial thickening, fibrosis, and stiffness …

… Because arterial compliance is a marker of vascular health and it can be modulated acutely
… chronic arginase inhibition on vascular stiffness. Overall, OC had a significantly lower arterial …

… contributes to aging-associated EC dysfunction and arterial stiffening. In aged rats, the
upregulation of iNOS activity in blood vessels induces the S-nitrosylation and activation of …

… Arginase, an enzyme that is released from red blood cells, … administered is metabolized
by arginase rather than NOS. … endothelial cell arginase, essentially “adding fuel to the fire.” …

… NO bioavailability has also been clearly demonstrated to modulate arterial stiffness [90].
However, vessel stiffness can also modulate endothelial cell signaling in response to luminal …

… /arginase molar ratios; 3) the two enzymes have comparable activities at higher l-arginine
concentrations, irrespective of the NOS/arginase molar ratio; and 4) arginase … Arterial stiffness …

… Our finding of greater stiffness (reduced compliance) of isolated carotid arteries from diabetic
WT mice versus their nondiabetic WT controls is in line with our findings of greater coronary …

… Second hand cigarettes exposure leads to increased total arginase activity and eNOS …
Arginase activation is the primary mechanism of vascular stiffness and endothelial vascular …

… Arginase Inhibition Restores Arterial Compliance to Normal in ApoE −/− Mice We next
investigated the effect of arginase inhibition on vascular stiffness, a marker of vascular health in …