High Efficiency and Problems of Chemiluminescence Assay‐Detected Aldosterone‐To‐Renin Ratio in Practical Primary Aldosteronism Screening

W Lin, Y Li, D Chen, Z Yao, H Xu… - International Journal …, 2020 - Wiley Online Library
… The screening test for primary aldosteronism is benefit for minimizing damage to the patient…
assay, a newly developing method, and prompted its high efficiency in primary aldosteronism

[HTML][HTML] Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system

PM O'Shea, TP Griffin, GA Browne, N Gallagher… - Practical Laboratory …, 2017 - Elsevier
… The recommended approach to screening for primary aldosteronism (PA) in at-risk populations
… However, lack of assay standardisation mandates the need for method-specific decision …

[PDF][PDF] Establishment of reference values for endocrine tests. III: primary aldosteronism

SJ Baas, E Endert, E Fliers, MF Prummel… - Neth J Med, 2003 - njmonline.nl
Background: In our laboratory well-defined reference values for the screening test and
confirmation test used in the diagnosis of primary aldosteronism were lacking. In this study we …

Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies

A Hannemann, M Bidlingmaier… - European Journal of …, 2012 - academic.oup.com
… The inter- and intra-assay coefficients of variation (CV) of the PAC assay were 15.7 and 5.4…
The inter- and intra-assay CV of the PRC assay were 5.0 and 3.6% at low concentrations and …

The challenge of more robust and reproducible methodology in screening for primary aldosteronism

RD Gordon - Journal of hypertension, 2004 - journals.lww.com
Primary aldosteronism (PAL) is gaining recognition as an … of widely differing conditions of
assay) plasma renin activity (PRA… More reproducible assays are essential at this critical time for …

A Renin-ssance in Primary Aldosteronism Testing: Obstacles and Opportunities for Screening, Diagnosis, and Management

JE Raizman, EP Diamandis, D Holmes… - Clinical …, 2015 - academic.oup.com
… aldosterone, meaning that all assays, whether commercial or lab … Furthermore, both PRA and
DRC assays are vulnerable to … PRA and DRC (mass assays) are both widely used methods …

Novel chemiluminescent immunoassay to measure plasma aldosterone and plasma active renin concentrations for the diagnosis of primary aldosteronism

K Teruyama, M Naruse, M Tsuiki… - Journal of Human …, 2022 - nature.com
… diagnosis of primary aldosteronism (PA). In Japan, although PAC and ARC are measured by
radioimmunoassay and immunoradiometric assay, … The results of both assays are obtained …

Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents

P Mulatero, M Stowasser, KC Loh… - The Journal of …, 2004 - academic.oup.com
Primary aldosteronism (PA) is a common form of endocrine hypertension previously believed
to account for less than 1% of hypertensive patients. Hypokalemia was considered a …

The expanding spectrum of primary aldosteronism: implications for diagnosis, pathogenesis, and treatment

A Vaidya, P Mulatero, R Baudrand… - Endocrine …, 2018 - academic.oup.com
… that assays on … of “primary aldosteronism” (7), and by the end of that year, at least 30 similar
cases were recognized (8). Importantly, the concept of primary vs secondary aldosteronism

Primary aldosteronism: diagnosis, localization, and treatment

MH Weinberger, CE GRIM, JW HOLLIFIELD… - Annals of Internal …, 1979 - acpjournals.org
… to diagnose primary aldosteronism. The biochemical diagnosis of primary aldosteronism has
… Plasma renin activity was suppressed below the limits of sensitivity of the assay in many but …