… TGF-β may be a downstream mediator of PDGFR-β to induce … β and PDGFR-β in the barrier
function of endothelial cell/pericyte co-culture that is a useful in vitro model of BBB. PDGFR-β …

… Binding of PDGF-BB to PDGFRβ on pericytes induces … release TGF-β to enhance the brain
endothelial barrier integrity [… factor, to regulate the endothelial barrier function [18]. Therefore, …

… (PDGFRs) are a subfamily of tyrosine kinase receptors including 2 members, PDGFR-α and
PDGFR-β, … lines of evidence have suggested that PDGFRs, especially PDGFR-α, may be …

… (PDGFR), which is also targeted by imatinib [27]. However, recent studies have implicated the
Abl kinases in the regulation of endothelial barrier function [… -cadherin or β-catenin tyrosine …

… The platelet-derived growth factor receptor β (PDGFRβ) is expressed in brain pericytes during
cell migration and angiogenesis, and it has also been found in minor part on the surface of …

… The PDGF-BB ligand and PDGFRβ interactions mediate … and blood-brain barrier, with PDGFRβ
expressed by pericytes [79]. … PDGFR-β as a positive regulator of tissue repair in a mouse …

… (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the
development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB …

… Blood–brain barrier (BBB) dysfunction underlies the … of tight junction proteins and
PDGFRβ-expressing pericyte … are mediated by PDGFRα and -β in preclinical studies including …

… PDGFRβ in response to PDGFBB secreted by endothelial cells also plays crucial homeostatic
functions… brain barrier (BBB) breach [Color figure can be viewed at wileyonlinelibrary.com] …

… showing active β-catenin … PDGFR-β expressed by pericytes, thereby promoting pericyte
recruitment to the immature vascular structures. Mice lacking either PDGF-B or PDGFR-β show a …