J Zheng, S Hu, J Wang, X Zhang, D Yuan… - Pharmaceutical …, 2021 - Taylor & Francis
… of autophagy was significantly reduced in agingrat brain, and ICA intervention can increase autophagy … neuronal dysfunction mainly through improve basalautophagy level in agingrat. …
H Huang, T Wang, L Wang, Y Huang, W Li, Y Hu… - Experimental …, 2023 - Elsevier
… decrease in basalautophagy in cardiomyocytes is a significant contributor to aging-related … The AMPK/mTOR/ULK1 signaling pathway is a key target for regulating autophagy. SPJ has …
Y Liu, S Shi, Z Gu, Y Du, M Liu, S Yan, J Gao, J Li… - Age, 2013 - Springer
… rat islets decreased gradually with aging. LC3-II puncta formation was significantly reduced in 24-month-old rats compared to 4- and 14-month-old rats … induces basalautophagy with no …
Y Gong, Y He, Y Gu, RF Keep, G Xi, Y Hua - 2011 - Springer
… rats. In conclusion, ICH causes more severe autophagy and neurological deficits in aged rats. … The ratio of LC3-II to LC3-I in the ipsilateral basal ganglia of agingrats was much higher …
E Bergamini, G Cavallini, A Donati… - Annals of the New York …, 2007 - Wiley Online Library
… Basal oxygen and sugar consumption are quite constant in … ; thus, the rate of aging and longevity in any given species may … stimulation of autophagy retards the process of aging in rats. …
AM Cuervo, E Bergamini, UT Brunk, W Dröge… - Autophagy, 2005 - Taylor & Francis
… rats, dietary anti-aging intervention preserved the juvenile amino acid and hormone regulation of autophagy.… However, a second affect on autophagy, through modulating basal insulin …
T Yamamoto, Y Takabatake, T Kimura, A Takahashi… - Autophagy, 2016 - Taylor & Francis
… how autophagy is involved in kidney aging. Unexpectedly, the basalautophagic activity was … In conclusion, we report that an age-dependent elevation in basalautophagy plays a crucial …
S Wang, Q Sun, B Xiang, XJ Li - Clinical and Investigative …, 2013 - utpjournals.press
… Instead of hampering the function of β cells, the degradation of cellular components by basal autophagy is essential for the maintenance of normal architecture and function of β cells [7,…
A Donati, G Recchia, G Cavallini… - The Journals of …, 2008 - academic.oup.com
… from 16- to 18-hour-fasted rats. Cell suspension (10 6 cells/… –fed rats a significant decline in the autophagic proteolysis of … –fed rats, no further decrease in basalautophagic proteolysis …