Transcription factor–DNA binding: beyond binding site motifs

S Inukai, KH Kock, ML Bulyk - Current opinion in genetics & development, 2017 - Elsevier
… However, we still lack both a comprehensive compendium of features that influence TF
binding and an understanding of how these pieces fit together. Furthermore, we are just …

Transcription factors: specific DNA binding and specific gene regulation

AL Todeschini, A Georges, RA Veitia - Trends in genetics, 2014 - cell.com
… by transcription factors (TFs) that recruit the transcriptional … TFs recognize similar consensus
DNA-binding sites and a genome can … Although nonfunctional binding may influence gene …

Mechanisms of transcription factor selectivity

Y Pan, CJ Tsai, B Ma, R Nussinov - Trends in Genetics, 2010 - cell.com
… How do TFs recognize specific binding sites among the … binding of TFs to coregulators,
that prior binding events can lead to selective DNA binding, and that selectivity is influenced by …

Factors influencing the identification of transcription factor binding sites by cross-species comparison

LA McCue, W Thompson, CS Carmack… - Genome …, 2002 - genome.cshlp.org
… with respect to phylogenetic footprinting of transcription factor (TF) binding sites in the γ-…
coli genes that have experimentally identified TF binding sites upstream of the gene, with …

Insights from genomic profiling of transcription factors

PJ Farnham - Nature Reviews Genetics, 2009 - nature.com
… A crucial question in the field of gene regulation is whether the location at which a
transcription factor binds influences its effectiveness or the mechanism by which it regulates …

Structural insights into how 5-hydroxymethylation influences transcription factor binding

L Lercher, MA McDonough, AH El-Sagheer… - Chemical …, 2014 - pubs.rsc.org
binding of both transcription factors. The modification type, 5mC or 5hmC, was not
observed to influence binding affinity to USF or MAX within our limits of detection. USF binding

[HTML][HTML] Determinants of transcription factor regulatory range

CH Chen, R Zheng, C Tokheim, X Dong, J Fan… - Nature …, 2020 - nature.com
… over which transcription factor (TF) binding influences gene … ranges of regulatory influence,
chromatin-binding preferences, and … Our results suggest that considering TF type, binding

Nucleosomal context of binding sites influences transcription factor binding affinity and gene regulation

Z Dai, X Dai, Q Xiang, J Feng - Genomics, Proteomics and …, 2009 - academic.oup.com
… of the associated binding sites. We further demonstrated that nucleosomal context of binding
sites is … We conclude that nucleosomal context of binding sites influences TF binding affinity, …

Understanding transcriptional regulation by integrative analysis of transcription factor binding data

C Cheng, R Alexander, R Min, J Leng, KY Yip… - Genome …, 2012 - genome.cshlp.org
Statistical models have been used to quantify the relationship between gene expression and
transcription factor (TF) binding signals. Here we apply the models to the large-scale data …

Unraveling determinants of transcription factor binding outside the core binding site

M Levo, E Zalckvar, E Sharon, ACD Machado… - Genome …, 2015 - genome.cshlp.org
… These observations demonstrate the need for a more comprehensive understanding of
the various factors influencing TF binding to regulatory sequences, going beyond the …