On the biochemical mode of action of levamisole: an update

J Van Wauwe, PAJ Janssen - International journal of …, 1991 - Elsevier
Levamisole (LEV) is a drug with a dual career. Originally introduced as an anthelminthic
agent in the mid-1960s, it soon revealed itself as a compound capable of increasing defective …

Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57

RJ Martin, AP Robertson - Parasitology, 2007 - cambridge.org
… and review the mode of action of levamisole and pyrantel … of Ascaris muscle to levamisole
or pyrantel is affected by the … a cholinergic anthelmintic like levamisole or pyrantel depends on …

Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole

RJ Martin, S Verma, M Levandoski, CL Clark, H Qian… - Parasitology, 2005 - cambridge.org
… Here we review recent studies on the mode of action of the cholinergic anthelmintics (levamisole,
pyrantel etc.). We also include material from studies on the free living nematode …

The levamisole story

PAJ Janssen - Progress in Drug Research/Fortschritte der …, 1976 - Springer
In the early 1960s our laboratory was engaged in a research program designed to find a
superior anthelmintic drug. We wanted it to be chemically unrelated to known drugs, potent, safe…

Understanding molecular mechanisms in multivariant actions of levamisole as an anti-helminthic, anti-inflammatory, antioxidant, anti-neoplastic and …

ML Chandy, C Soman, SP Kumar, S Kurup… - Journal of Oral and …, 2016 - Elsevier
Levamisole is a potent drug with a wide range of actions. This review article highlights the
actions, interactions and side effects of levamisole. It is … of applications of levamisole which can …

Effects of therapeutic and toxic doses of levamisole on thyroid hormones and some biochemical parameters in sheep

A Atessahin, I Karahan, I Pirincci - Cell Biochemistry and …, 2004 - Wiley Online Library
… It is obvious that levamisole is of major significance in terms of … of levamisole, administrated
orally at therapeutic and toxic doses, on thyroid hormone levels and some biochemical

Levamisole, the story and the lessons

WKP Amery, JPJM Bruynseels - International journal of …, 1992 - Elsevier
Levamisole was also found to block the action of another immunosuppressive factor, …
Obviously, the mode of action of levamisole is still far from completely understood and many …

Levamisole receptors: a second awakening

RJ Martin, AP Robertson, SK Buxton, RN Beech… - Trends in …, 2012 - cell.com
… elegans, that levamisole activates only one conductance subtype of 30 pS, which is not
activated by nicotine and is pharmacologically different from some of the parasite levamisole

The biochemical basis of anthelmintic action and resistance

P Köhler - International journal for parasitology, 2001 - Elsevier
… Members of one of this drug category act as acetylcholine agonists and include levamisole,
the tetrahydropyrimidines (eg pyrantel and morantel) and some other structurally related …

Use of free living stages to study the effects of thiabendazole, levamisole, pyrantel and ivermectin on the fine structure of Haemonchus contortus and …

F Beugnet, D Kerboeuf, JC Nicolle, D Soubieux - Veterinary parasitology, 1996 - Elsevier
… Pyrantel has the same mode of action as levamisole but no specific damages were observed
in this study, perhaps due to the reversibility of the effect. A pluriconcentric formation of the …