Ageing and low-level chronic inflammation: the role of the biological clock

B Colombini, M Dinu, E Murgo, S Lotti, R Tarquini… - Antioxidants, 2022 - mdpi.com
biological clocks in inflammatory and immune competent cells [16,17]. Furthermore, circadian
… enriching the signaling pathways involved in inflammatory processes, such as the nuclear …

Therapeutics on the clock: Circadian medicine in the treatment of chronic inflammatory diseases

H Jacob, AM Curtis, CJ Kearney - Biochemical pharmacology, 2020 - Elsevier
Circadian clocks govern the daily rhythms observed in our physiology and behavior. … a
pronounced circadian pattern with high levels during the active phase and low levels during the …

Adaptive immunity, chronic inflammation and the clock

KJ Gray, JE Gibbs - Seminars in Immunopathology, 2022 - Springer
… Here, we discuss how the circadian clock exerts influence over the function of the … circadian
clock has negative impact on development and progression of these chronic inflammatory

Relationship between the biological clock and inflammatory bowel disease

J Giebfried, A Lorentz - Clocks & Sleep, 2023 - mdpi.com
… IBD is a group of chronic inflammatory diseases affecting the gastrointestinal tract. Crohn’s …
elevated levels of occludin and claudin-1, mice lacking CLOCK had persistently low levels of …

[HTML][HTML] The circadian clock regulates inflammatory arthritis

LE Hand, TW Hopwood, SH Dickson… - The FASEB …, 2016 - ncbi.nlm.nih.gov
chronic inflammatory conditions, the clock actively represses … circadian clock. In this study,
we characterized the role of the circadian clock in a well-established model of inflammatory

Training the circadian clock, clocking the drugs, and drugging the clock to prevent, manage, and treat chronic diseases

G Sulli, ENC Manoogian, PR Taub, S Panda - Trends in pharmacological …, 2018 - cell.com
circadian clock in a central role. Here, we review recent advancements on how to enhance
our circadian clock … , and pharmacological targeting of circadian clock components that are …

Rheumatoid arthritis and the biological clock

A De Cata, L D'Agruma, R Tarquini… - Expert Review of …, 2014 - Taylor & Francis
circadian clock circuitry on immune system function as well as of inflammation on the function
of the biological clock. … RA is characterized by chronic inflammation involving the synovial …

The Biological Clock in Inflammation and Sleep Switch Alterations

M Bentivoglio, M Nygård, M Palomba… - Neuroimmunology of …, 2007 - Springer
… as components of systemic inflammation occur also in normal … in inflammation outside the
nervous system (eg, histamine) and proinflammatory cytokines may affect the biological clock

Circadian clocks and inflammation: reciprocal regulation and shared mediators

N Cermakian, S Westfall, S Kiessling - Archivum immunologiae et …, 2014 - Springer
… between the circadian clock and the immune system, in particular the inflammatory pathways.
… shock and produce lower levels of pro-inflammatory cytokines (Liu et al. 2006). Further, the …

Working against the biological clock: a review for the Occupational Physician

A Copertaro, M Bracci - Industrial health, 2019 - jstage.jst.go.jp
circadian clock, regulates the circadian cycles and adjusts them to the metabolic rhythms;
since it is involved in lipid metabolism, adipogenesis, glucose homeostasis, and inflammation, …