… organofluorine compounds. Accordingly, this book highlights the importance of organofluorine
compounds … ) is devoted to the synthesis and biomedical applications of 18F-PET tracers. …

… , biological medical agents principally act on proteins on the cell membrane and targets
outside the cell. Although many technological issues with the use of biological medicines remain…

… and pharmacology of organofluorine compounds. Extensive … the properties of organic
compounds so dramatically? Three … fat-solubility of organofluorine compounds, and this feature is …

… first natural organofluorinated compound to be identified in 1943 as a metabolite from
Dichapetalum cymosum [2]. The low bioavailability of natural fluorinated compounds and fluorine’s …

… The extraordinary potential of fluorine-containing biologically relevant molecules in
peptide/protein chemistry, medicinal chemistry, chemical biology, pharmacology, and drug discovery …

… Accordingly, a wide variety of fluorine-containing compounds based either on known natural
products or on new skeletons have been synthesized and subjected to biological evaluation…

… fluorine and organofluorine groups very attractive in medicinal chemistry and chemical
biology. Therefore, it is common to explore fluorine-containing analogs of lead compounds for …

… and advancement in organofluorine chemistry has eminently … -containing compounds with
applications in medicine. These … endogenous compounds markedly exchange their biological …

… compound can cause dramatic changes on the compound’s chemical, physical, and
biological … in rationalizing diverse observations in organofluorine structural chemistry. Another …

… methods applicable to organofluorine compounds, including … the future directions in
organofluorine chemistry at the … the synthesis of a variety of organofluorine compounds and (ii) …