Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
bispecific antibodies by combining nonoverlapping specificities and identified five bispecific
antibodies that inhibit SARS-CoV-… of action, three bispecific antibodies cross-linked adjacent …

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
antibodies (B38 and H4) blocking SARS-CoV-2 … bispecific monoclonal antibody (bsAb)
based on B38 and H4. bsAb15 has greater neutralizing efficiency than these parental antibodies, …

[HTML][HTML] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

R De Gasparo, M Pedotti, L Simonelli, P Nickl… - Nature, 2021 - nature.com
… We have shown that the CoV-X2 bispecific antibody is more effective than the related … like
bispecific antibodies are therefore worth adding to the tools that we use to address SARS-CoV-…

[HTML][HTML] Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
… are highly effective in an in vivo model of SARS-CoV-2 infection We tested the bispecific
antibodies for efficacy against SARS-CoV-2 infection in the well-established Syrian hamster …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
… two key steps of SARS-CoV-2 entry, we generated a human-derived, IgG1-like bispecific
antibody, Bi-Nab 35B5-47D10 , based on two human neutralizing antibodies, 35B5 and 47D10, …

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617

L Peng, Y Hu, MC Mankowski, P Ren, RE Chen… - Nature …, 2022 - nature.com
SARS-CoV-2 RBD. We generate a bispecific antibody with two antigen-recognition variable
regions from two of the top mAb clones against SARS-CoV-2 RBD. These monospecific and …

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Y Wang, M Liu, Y Shen, Y Ma, X Li, Y Zhang, M Liu… - Cell Discovery, 2022 - nature.com
bispecific antibodies using GW01 in combination with the SARS-CoV-2 RBD-specific potent
antibody … We measured the neutralizing activities of these six bispecific antibodies against …

A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
… that our bispecific antibody platform could serve as a universally applicable strategy
against both SARS-CoV-2 and its related strains by simply switching RBD-specific antibodies. …

A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB. 1.16, BQ. 1.1 and sarbecoviruses

Y Wang, A Hao, P Ji, Y Ma, Z Zhang, J Chen… - Nature …, 2024 - nature.com
bispecific antibodies, we performed a neutralization assay using a panel of twenty-eight
pseudoviruses, including SARS-CoV-2 … as SARS-CoV, WIV1, and RS3367. Remarkably, G7-Fc …

An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant

M Yuan, Y Zhu, G Liu, Y Wang, G Wang, G Zhang… - One Health …, 2023 - Springer
… designed an RBD bispecific antibody that potently neutralizes a range of SARS-CoV-2 variants…
than its parental antibodies against SARS-CoV-2 VBMs and VOCs. Our data indicate that …