Bispecific antibodies and its applications: a novel approach for targeting SARS-Cov-2

AK Shukla, S Misra - Journal of Basic and Clinical Physiology and …, 2023 - degruyter.com
… The bispecific antibodies (bsAbs) with two epitope … of bispecific antibody attached to the
two targets is shown in Figure 1. Hybridoma cell lines, which are a combination of an antibody-…

[HTML][HTML] IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

MR Chang, L Tomasovic, NA Kuzmina, AJ Ronk… - Nature …, 2022 - nature.com
Antibody cocktails are being employed to mitigate these … Here we present two anti-SARS-CoV-2
spike binding antibodies… , fully-human IgG-like bispecific antibodies (BsAb). Prophylaxis …

[HTML][HTML] Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Z Ku, X Xie, J Lin, P Gao, B Wu, A El Sahili, H Su… - Nature …, 2022 - nature.com
… Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared …
antibodies using authentic SARS-CoV-2 virus 21 . Antibody 14-crs-06 neutralized SARS-CoV-…

[HTML][HTML] A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants

A Chiyyeadu, G Asgedom, M Bruhn, C Rocha… - Clinical …, 2024 - Elsevier
… to generate broadly neutralizing antibodies are urgently needed. Here, we describe a
tetravalent bispecific antibody, A7A9 TVB, which actively neutralized many SARS-CoV-2 variants …

[PDF][PDF] Bispecific antibodies as an alternative to antibody cocktails for SARS-CoV-2: a mini-review

G Yuen, S Bhanot, J Steen, M Syed… - J Immunol …, 2020 - immunologyresearchjournal.com
… that bispecific antibodies have a broader recognition of variant strains than cocktail antibodies.
… to explore the clinical benefits of bispecific antibodies for SARS-CoV-2 and the emerging …

[HTML][HTML] Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

C Li, W Zhan, Z Yang, C Tu, G Hu, X Zhang, W Song… - Cell, 2022 - cell.com
… We demonstrated that this bispecific antibody can be effectively … efficacy in mouse models
of SARS-CoV-2 infections. Importantly, this … Here, we report the design of a bispecific antibody

[HTML][HTML] Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual

D Guerra, T Beaumont, L Radić, G Kerster… - Iscience, 2023 - cell.com
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has remained a medical threat due to the evolution of multiple variants that acquire resistance …

[HTML][HTML] Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

H Ma, H Zong, J Liu, Y Yue, Y Ke, Y Liao… - Acta Pharmacologica …, 2023 - nature.com
SARS-CoV-1. Our results highlight the feasibility of using the VSV-SARS-CoV-2 system
to develop SARS-CoV-2 antibody … strategies to address the mutational escape of SARS-CoV-2. …

Highly potent bispecific sybodies neutralize SARS-CoV-2

JD Walter, CA Hutter, AA Garaeva, M Scherer… - 2020 - research.rug.nl
… For neutralization of live SARS-CoV-… SARS-CoV-1 and SARS-CoV-2. The same conserved
epitope is also recognized by the human 291 antibodies CR3022 (isolated from a SARS-CoV-…

[HTML][HTML] Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L Radić, K Sliepen, V Yin, M Brinkkemper… - Iscience, 2023 - cell.com
… Here we used controlled Fab-arm exchange to produce bsAbs that neutralize SARS-CoV
and SARS-CoV-2 variants, including Omicron and its subvariants, by combining potent …