S Kumar, A Chandele, A Sharma - PLoS pathogens, 2021 - journals.plos.org
… These bispecific NAbs neutralize wild-type SARS-CoV-2, its VOCs, and escape mutants … bispecific NAbs are promising next-generation cost-effective therapeutics against SARS-CoV-2 …
H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
… both SARS-CoV-1 and WT SARS-CoV-2. Based on X-ray crystallography, we engineered a bispecific … Bispecificantibody 2-3-Fc designed by fusing aSA3-Fc to nonoverlapping aRBD-2 …
T Zhu, Y Xiao, X Meng, L Tang, B Li, Z Zhao… - Journal of …, 2021 - Springer
… a convalescent SARS-CoV-1 patient and a SARS-CoV-2 … of a single neutralizing antibody, the SARS-CoV-2 strain may … monoclonal antibody combination against SARScoronavirus …
X Wu, L Cheng, M Fu, B Huang, L Zhu, S Xu, H Shi… - Cell reports, 2021 - cell.com
… bispecific for the RBD of SARS-CoV-2 and human serum albumin (HSA). This bispecific antibody exhibited potent inhibitory activity against the wild type and variants of SARS-CoV-2, …
L Radić, K Sliepen, V Yin, M Brinkkemper… - Iscience, 2023 - cell.com
… 34 to produce bsAbs that neutralize SARS-CoV and SARS-CoV-2 variants, … SARS-CoV-2-specific neutralizing antibodies with 36 broader antibodies that also neutralize SARS-CoV. We …
… SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against SARS-CoV… This naturally elicited bispecific monomeric nanobody establishes an uncommon …
… -format IgG1-like bispecificantibody 11 resulting from the … CoV-X2 in vitro, we first used SARS-CoV-2 pseudoviruses 16 . The bispecific neutralized pseudovirus carrying wild-type SARS…
SE Sedykh, VV Prinz, VN Buneva… - Drug design …, 2018 - Taylor & Francis
… Citation133 BsAbs recognizing several epitopes of the NP antigen of SARScoronavirus (causing severe acute respiratory syndrome) and binding to horseradish peroxidase were used …
HH Sunwoo, A Palaniyappan, A Ganguly… - Journal of virological …, 2013 - Elsevier
… antibodies against SARSCoV S1 antigen were generated by hybridomatechnology. ► Bispecificantibody … Mono- and bispecificantibodies were evaluated by sandiwichELISA for …