Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

H Ma, H Zong, J Liu, Y Yue, Y Ke, Y Liao… - Acta Pharmacologica …, 2023 - nature.com
SARS-CoV-1. Our results highlight the feasibility of using the VSV-SARS-CoV-2 system
to develop SARS-CoV-2 antibody … strategies to address the mutational escape of SARS-CoV-2. …

Current status of therapeutic monoclonal antibodies against SARS-CoV-2

S Kumar, A Chandele, A Sharma - PLoS pathogens, 2021 - journals.plos.org
… These bispecific NAbs neutralize wild-type SARS-CoV-2, its VOCs, and escape mutants …
bispecific NAbs are promising next-generation cost-effective therapeutics against SARS-CoV-2 …

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …

H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
… both SARS-CoV-1 and WT SARS-CoV-2. Based on X-ray crystallography, we engineered a
bispecificBispecific antibody 2-3-Fc designed by fusing aSA3-Fc to nonoverlapping aRBD-2 …

Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

T Zhu, Y Xiao, X Meng, L Tang, B Li, Z Zhao… - Journal of …, 2021 - Springer
… a convalescent SARS-CoV-1 patient and a SARS-CoV-2 … of a single neutralizing antibody,
the SARS-CoV-2 strain may … monoclonal antibody combination against SARS coronavirus

[PDF][PDF] A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

X Wu, L Cheng, M Fu, B Huang, L Zhu, S Xu, H Shi… - Cell reports, 2021 - cell.com
bispecific for the RBD of SARS-CoV-2 and human serum albumin (HSA). This bispecific
antibody exhibited potent inhibitory activity against the wild type and variants of SARS-CoV-2, …

[PDF][PDF] Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L Radić, K Sliepen, V Yin, M Brinkkemper… - Iscience, 2023 - cell.com
… 34 to produce bsAbs that neutralize SARS-CoV and SARS-CoV-2 variants, … SARS-CoV-2-specific
neutralizing antibodies with 36 broader antibodies that also neutralize SARS-CoV. We …

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

L Hanke, H Das, DJ Sheward… - Nature …, 2022 - nature.com
SARS-CoV. Furthermore, we demonstrate the therapeutic potential of the nanobody against
SARS-CoV… This naturally elicited bispecific monomeric nanobody establishes an uncommon …

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

R De Gasparo, M Pedotti, L Simonelli, P Nickl… - bioRxiv, 2021 - biorxiv.org
… -format IgG1-like bispecific antibody 11 resulting from the … CoV-X2 in vitro, we first used
SARS-CoV-2 pseudoviruses 16 . The bispecific neutralized pseudovirus carrying wild-type SARS

Bispecific antibodies: design, therapy, perspectives

SE Sedykh, VV Prinz, VN Buneva… - Drug design …, 2018 - Taylor & Francis
… Citation133 BsAbs recognizing several epitopes of the NP antigen of SARS coronavirus (causing
severe acute respiratory syndrome) and binding to horseradish peroxidase were used …

Quantitative and sensitive detection of the SARS-CoV spike protein using bispecific monoclonal antibody-based enzyme-linked immunoassay

HH Sunwoo, A Palaniyappan, A Ganguly… - Journal of virological …, 2013 - Elsevier
antibodies against SARS CoV S1 antigen were generated by hybridomatechnology. ►
Bispecific antibody … Mono- and bispecific antibodies were evaluated by sandiwichELISA for …