Biparatopic sybodies neutralize SARSCoV‐2 variants of concern and mitigate drug resistance

JD Walter, M Scherer, CAJ Hutter, AA Garaeva… - EMBO …, 2022 - embopress.org
… The multivalent bispecific … live SARS-CoV-2 we employed a classical virus neutralization
assay and confirmed that both sybodies successfully inhibited cell entry by infectious SARS-CoV

Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease

R De Gasparo, M Pedotti, L Simonelli, P Nickl… - 2021 - pesquisa.bvsalud.org
… novel animal model of SARS-CoV-2 infection with lung inflammation, CoV-X2 … bispecific
antibodies is feasible and effective, combining into a single molecule the advantages of antibody

Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARSCoV‐2

R Lázaro‐Gorines, P Pérez, I Heras‐Murillo… - Advanced …, 2023 - Wiley Online Library
… Administration of neutralizing antibodies (nAbs) has proved to be effective by providing
immediate protection against SARSCoV‐2. However, dual strategies combining virus

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

D Guerra, L Radić, M Brinkkemper, M Poniman… - bioRxiv, 2024 - biorxiv.org
… mAbs 7–9, additional strategies to combat SARS-CoV-2 have been 73 investigated. One
of … antibody-like constructs, such as bispecific antibodies (bsAbs). 75 Different SARS-CoV-2 …

[HTML][HTML] A neutralizing bispecific single-chain antibody against SARS-CoV-2 Omicron variant produced based on CR3022

K Yu, B Liu, H Yu, C Sun, X Wang, G Li… - Frontiers in Cellular …, 2023 - frontiersin.org
… -29 and 16-3022 against SARS-CoV-2 original strain and Omicron … SARS-CoV RBD-targeted
scFv S3022 could play a synergistic role with other SARS-CoV-2 RBD-targeted antibodies

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

TZ Yuan, C Lucas, VS Monteiro, A Iwasaki, ML Yang… - bioRxiv, 2022 - biorxiv.org
… In this paper, we highlight RBT-0813, a synthetic VHH bispecific antibody capable of binding
and neutralizing the SARS-CoV-2 Delta and Omicron variants. This bispecific antibody links …

[HTML][HTML] A spike-targeting bispecific T cell engager strategy provides dual layer protection against SARS-CoV-2 infection in vivo

F Li, W Xu, X Zhang, W Wang, S Su, P Han… - Communications …, 2023 - nature.com
… re-neutralization abilities against mutated SARS-CoV-2 variants 30,31,… antibodies against
escaping variants of SARS-CoV-2, such as antibody cocktails 53,54 and bispecific antibodies

[HTML][HTML] Bispecific antibodies: from research to clinical application

J Ma, Y Mo, M Tang, J Shen, Y Qi, W Zhao… - Frontiers in …, 2021 - frontiersin.org
… Finally, BsAb targeting of the nuclear plasmid protein of the SARS coronavirus immunoassay
antigen is superior to that by MoAb in terms of specificity, sensitivity, and signal strength …

[HTML][HTML] Bispecific antibodies and their applications

G Fan, Z Wang, M Hao, J Li - Journal of hematology & oncology, 2015 - Springer
Bispecific antibodies (BsAbs) have been posited as potential cancer therapeutic agents
for decades but have only recently begun to bear fruit. BsAbs show several advantages [5]: (1) …

[HTML][HTML] Engineering a novel antibody-peptide bispecific fusion protein against MERS-CoV

L Wang, J Xu, Y Kong, R Liang, W Li, J Li, J Lu… - Antibodies, 2019 - mdpi.com
… Like SARS-CoV, MERS-CoV is an enveloped virus using its spike (S) protein to enter target
… To generate the bispecific antibody-peptide inhibitor, the MERS-CoV S2-derived peptide …