Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
… these antibodies target multiple sites on the spike protein. We tested the bispecific antibodies
for binding to spike proteins … Only the bispecific antibodies whose two components both lost …

Designing of a bispecific antibody against SARS-CoV-2 spike glycoprotein targeting human entry receptors DPP4 and ACE2

R Ojha, K Gurjar, TS Ratnakar, A Mishra… - Human immunology, 2022 - Elsevier
… we have designed a bispecific antibody conjugated with anti-… 2 via blocking its self spike
protein and primary entry receptors… spike protein with D614G mutation as the target for bispecific

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
… high mutations in the spike protein and exhibit considerable … a potent bispecific MAb Bi-Nab
35B5-47D10 targeting spike RBD … Bispecific or multiple specific antibodies targeting different …

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
… (RBD) of the spike (S) glycoprotein of SARS-CoV-2 and block the binding between the S …
of activity of the antibodies, we expressed the RBD proteins with substitution mutations and …

[HTML][HTML] Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
antibodies target multiple sites on the spike protein. We tested the bispecific antibodies for
binding to variant spike proteins … Only the bispecific antibodies whose two components both …

[HTML][HTML] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

R De Gasparo, M Pedotti, L Simonelli, P Nickl… - Nature, 2021 - nature.com
… that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among
the … We have shown that the CoV-X2 bispecific antibody is more effective than the related …

Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

SA Lim, JA Gramespacher, K Pance, NJ Rettko… - MAbs, 2021 - Taylor & Francis
… a bispecific antibody that combines both neutralizing and non-neutralizing epitopes on
Spike-… Spike-RBD as a promising protein engineering strategy to rapidly improve the potency of …

Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19

T Zhu, Y Xiao, X Meng, L Tang, B Li, Z Zhao… - Journal of …, 2021 - Springer
… -CoV-2 spike protein to test the neutralization of the three types of nanovesicles [25].
Spike-… , in which the nucleotide sequence of the spike protein was taken from the SARS-CoV-2 …

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

T Inoue, Y Yamamoto, K Sato, Y Okemoto-Nakamura… - Iscience, 2024 - cell.com
… -62 (targeting a spike protein S2 subunit epitope adjacent to the known anti-S2 … bispecific
antibodies, which combine existing less effective anti-RBD antibodies with anti-S2 antibodies, …

Bispecific antibodies: design, therapy, perspectives

SE Sedykh, VV Prinz, VN Buneva… - Drug design …, 2018 - Taylor & Francis
… Immunoglobulins (antibodies [Abs]) are major protein components of the adaptive immune
system, directed against foreign compounds and infectious agents. The IgG molecule …