… we have designed a bispecificantibody conjugated with anti-… 2 via blocking its self spike protein and primary entry receptors… spikeprotein with D614G mutation as the target for bispecific …
M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
… high mutations in the spikeprotein and exhibit considerable … a potent bispecific MAb Bi-Nab 35B5-47D10 targeting spike RBD … Bispecific or multiple specific antibodies targeting different …
Z Li, S Li, G Zhang, W Peng, Z Chang, X Zhang… - Nature …, 2022 - nature.com
… (RBD) of the spike (S) glycoprotein of SARS-CoV-2 and block the binding between the S … of activity of the antibodies, we expressed the RBD proteins with substitution mutations and …
H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
… antibodies target multiple sites on the spikeprotein. We tested the bispecificantibodies for binding to variant spikeproteins … Only the bispecificantibodies whose two components both …
… that target the receptor-binding domain (RBD) of the SARS-CoV-2 spikeprotein are among the … We have shown that the CoV-X2 bispecificantibody is more effective than the related …
SA Lim, JA Gramespacher, K Pance, NJ Rettko… - MAbs, 2021 - Taylor & Francis
… a bispecificantibody that combines both neutralizing and non-neutralizing epitopes on Spike-… Spike-RBD as a promising protein engineering strategy to rapidly improve the potency of …
T Zhu, Y Xiao, X Meng, L Tang, B Li, Z Zhao… - Journal of …, 2021 - Springer
… -CoV-2 spikeprotein to test the neutralization of the three types of nanovesicles [25]. Spike-… , in which the nucleotide sequence of the spikeprotein was taken from the SARS-CoV-2 …
T Inoue, Y Yamamoto, K Sato, Y Okemoto-Nakamura… - Iscience, 2024 - cell.com
… -62 (targeting a spikeprotein S2 subunit epitope adjacent to the known anti-S2 … bispecific antibodies, which combine existing less effective anti-RBD antibodies with anti-S2 antibodies, …
SE Sedykh, VV Prinz, VN Buneva… - Drug design …, 2018 - Taylor & Francis
… Immunoglobulins (antibodies [Abs]) are major protein components of the adaptive immune system, directed against foreign compounds and infectious agents. The IgG molecule …