… fusion of two key steps of SARS-CoV-2 entry, we generated a human-derived, IgG1-like
bispecific antibody, Bi-Nab 35B5-47D10 , based on two human neutralizing antibodies, 35B5 …

… -2 neutralizing antibodies (NAbs). In this study, we explored the possibility of combating
the Omicron and BA.2 by constructing bispecific antibodies based on non-Omicron NAbs. We …

… RBD bispecific antibody that potently neutralizes a range of SARS-CoV-2 variants, including
the currently dominant Omicron … than its parental antibodies against SARS-CoV-2 VBMs and …

… variants BA.1 and BA.2 . Therefore, we constructed bispecific antibodies using 7F3 and
GW01 to see if these two antibodies in IgG-like structure format could enhance the breadth and …

… structures of a broadly potent human bispecific antibody CoV2-0213 against circulating
Omicron subvariants. a A scheme of bsAb design. Antibody domains are colored according to …

… to the current coronavirus disease 2019 (COVID-19) vaccines … syndrome coronavirus 2
(SARS-CoV-2) neutralizing antibodies … the Omicron variant by constructing bispecific antibodies …

… aRBD-2, we engineered a novel bispecific Nb dimer termed 2-… that 2-3-Fc was effective in
combating Omicron infection through … Bispecific antibody 2-3-Fc designed by fusing aSA3-Fc to …

… potent neutralizing activity of two BscAbs 16-29 and 16-3022 against SARS-CoV-2
original strain and Omicron variant infection. In addition, we also found that SARS-CoV RBD-targeted …

… Here, we report the identification of two highly conserved regions on the Omicron variant …
Here, we report the design of a bispecific antibody composed of two different human single-…

… antibodies (mAbs) and continuously emerging severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) variants has favored the virus, … a reproducible bispecific antibody (bsAb)-…