[HTML][HTML] Therapeutic antibodies and alternative formats against SARS-CoV-2

RR Winiger, L Perez - Antiviral Research, 2024 - Elsevier
two highly conserved regions on the RBD of the Omicron … early neutralizing antibody response
against SARS-CoV-2 and … isotype molecules or bispecific antibodies might be considered …

A multivalent and thermostable nanobody neutralizing SARS-CoV-2 omicron (B. 1.1. 529)

Y Lu, Q Li, H Fan, C Liao, J Zhang, H Hu… - International Journal …, 2023 - Taylor & Francis
… We also carried out the SARS-CoV-2 WT and Omicron (B.1.1.… neutralized WT SARS-CoV-2
pseudotyped virus with an IC 50 … Furthermore, although the previously dominant Omicron

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

H Ma, H Zong, J Liu, Y Yue, Y Ke, Y Liao, H Tang… - bioRxiv, 2022 - biorxiv.org
Omicron, as well as SARS-CoV-1. Our results highlight the feasibility of using the VSV-SARS-CoV-2
system to develop SARS-CoV-2 antibody … the mutational escape of SARS-CoV-2. …

Engineered Therapeutic Antibody Against SARS-CoV-2

M Chulanetra - Current Clinical Microbiology Reports, 2023 - Springer
two antibodies as antibody cocktails or bispecific antibodies may overcome antibody escape
mutations of the SARS-CoV-2 … The emerging SARS-CoV-2 Omicron variant contains > 30 …

Preclinical evaluation of ISH0339, a tetravalent broadly neutralizing bispecific antibody against SARS-CoV-2 with long-term protection

H Yang, Y Chen, D Jiang, X Feng, Y Xu… - Antibody …, 2023 - academic.oup.com
bispecific antibody ISH0339, as a potential candidate for long-term and broad protection
against COVID-19SARS-CoV-2 Delta and Omicron sublineages. In a mesocricetus auratus live …

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants

A Hao, W Song, C Li, X Zhang, C Tu, X Wang… - … and Targeted Therapy, 2023 - nature.com
bispecific single-domain antibody bn03 could resist the immune escape of the SARS-CoV-2
Omicron … 1a, bn03 could broadly neutralize all the six Omicron variants, with IC 50 values of …

Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors

PAB Weidenbacher, E Waltari… - Nature Chemical …, 2022 - nature.com
… show neutralizing activity against all SARS-CoV-2 VOCs tested, including Omicron and
BA.2. Furthermore, a bi-specific ReconnAb containing two non-neutralizing antibodies with non-…

First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variants

A Titong, S Gallolu Kankanamalage, J Dong… - Scientific Reports, 2022 - nature.com
… with key variants including Delta and Omicron, owing to its … bispecific and trispecific antibodies
based on anti-SARS-CoV… and S/ACE-2 blocking compared to bispecific antibodies and …

Targeting SARSCoV2 infection through CAR‐T‐like bispecific T cell engagers incorporating ACE2

M Dogan, L Kozhaya, L Placek… - Clinical & …, 2022 - Wiley Online Library
… a similar approach using bispecific antibodies (Bites) as T cell … SARS-CoV-2 by binding to
Spike proteins on the virus. To … with SARS-CoV, SARS-CoV-2 wild-type, Delta and Omicron

Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA. 1 and BA. 2 by biparatopic human VH domains

C Chen, JW Saville, MM Marti, A Schäfer, MH Cheng… - Iscience, 2022 - cell.com
… and potently neutralized VOCs including Omicron. Additionally, prophylactic treatment using
… a new potential therapeutic against SARS-CoV-2 variants including Omicron and highlight a …