Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants

X Chi, L Xia, G Zhang, X Chi, B Huang, Y Zhang… - Cell Discovery, 2023 - nature.com
… between the antibodies reported in PDB and current Omicron strains. Our results showed
that Omicron mutations affected the epitopes of most of the existing antibodies in Protein Data …

Engineered Nanovesicles Expressing Bispecific Single Chain Variable Fragments to Protect against SARS-CoV-2 Infection

L Tang, H Ding, Q Zeng, R Zhou, B Liu… - … Biomaterials Science & …, 2023 - ACS Publications
… (27) These S protein sequences were derived from the Wuhan-HU-1 (wild type) and the
Omicron SARS-CoV-2 variant, since the Omicron variant is currently the dominant mutated strain …

Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron Variants

W Du, P Jiang, Q Li, H Wen, M Zheng… - Microbiology …, 2023 - Am Soc Microbiol
… with neutralizing ability against SARS-CoV-2 prototype pseudovirus infection. Z14 and Z171
had neutralizing activities against SARS-CoV-2 Delta and Omicron pseudoviruses, which …

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA. 1 through a unique binding mode

D Zhao, L Liu, X Liu, J Zhang, Y Yin, L Luan… - Journal of …, 2022 - Springer
… with SARS-CoV-2 wild-type virus and most of the viruses of concern, ie, Alpha, Beta,
Gamma and Omicron variants. Strikingly, C5G2 has the highest potency against Omicron BA.1 …

IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

MR Chang, L Tomasovic, NA Kuzmina, AJ Ronk… - Nature …, 2022 - nature.com
… we present two anti-SARS-CoV-2 spike binding antibodies, … , fully-human IgG-like bispecific
antibodies (BsAb). Prophylaxis of … (Omicron), each containing a unique combination of spike …

Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants

Y Liu, Z Wang, X Zhuang, S Zhang, Z Chen… - Nature …, 2023 - nature.com
SARS-CoV-2 pseudoviruses for the two bispecific antibodies… activity of bispecific antibodies
against live SARS-CoV-2 wild … two orthogonal orientations of the SARS-CoV-2 Omicron BA.1 …

Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage

SL Gupta, RK Jaiswal - Molecular Biology Reports, 2022 - Springer
… The Omicron variant is a recent emerging threat of SARS-CoV-2 variants which raised
serious concern … While bispecific antibodies are constructed by combining two monoclonal …

Distinct conformations of SARS-CoV-2 Omicron spike protein and its interaction with ACE2 and antibody

M Lee, M Major, H Hong - International Journal of Molecular Sciences, 2023 - mdpi.com
SARS-CoV-2 spike protein with ACE2 and antibodies. Specifically, we focus on the distinct
conformations of the Omicron … of distinct conformations of the Omicron spike protein and its …

Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants

W Du, R Janssens, AZ Mykytyn, W Li… - Frontiers in …, 2023 - frontiersin.org
… hexavalent antibodiesantibody integrating three antigen binding domains exhibited
remarkable broad neutralization capacity against SARS-CoV-2 VOCs, including Omicron BA.1, BA.2

Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variants

JW Kim, K Heo, HJ Kim, Y Yoo, HS Cho, HJ Jang… - Antiviral Research, 2023 - Elsevier
… ) of SARS-CoV-2 isolated from human synthetic antibody library, we generated K202.B, a
novel engineered bispecific antibody … on a noncompeting pair of Omicron-specific and phage …