Methods used for the measurement of blood-brain barrier integrity

H Sun, H Hu, C Liu, N Sun, C Duan - Metabolic brain disease, 2021 - Springer
… disorders, suitable measurements are required to demonstrate integrity and functional
changes at the interfaces between the blood and brain tissue. Markers and plasma proteins with …

Nitric oxide and bloodbrain barrier integrity

VE Thiel, KL Audus - Antioxidants and Redox Signaling, 2001 - liebertpub.com
… The bloodbrain barrier (BBB) is comprised of the endothelial cells that line the capillaries …
enter into the brain passively. This review considers the role of NO and BBB integrity. Antioxid. …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
… have on signaling from gut to brain is now required. In this … blood-brain barrier integrity and
brain function, and the communication networks between the gastrointestinal tract and brain, …

A bloodbrain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
… The bloodbrain barrier is playing a critical role in controlling the influx and efflux of … the
brain’s metabolic activity as well as neuronal function. Thus, the functional and structural integrity

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

NR Saunders, KM Dziegielewska, K Møllgård… - Frontiers in …, 2015 - frontiersin.org
… In summary, labeled dextrans are valuable markers of blood-brain barrier integrity, which
in the small concentrations used appear to be non-toxic. The biotin labeled form is particularly …

Nanoparticle surface charges alter bloodbrain barrier integrity and permeability

PR Lockman, JM Koziara, RJ Mumper… - Journal of drug …, 2004 - Taylor & Francis
… , anionic and cationic charged NPs on BBB integrity and (2) NP brain permeability. …
bloodbrain barrier (BBB) is comprised of tight junction bound endothelia that serve to retard brain

Blood-brain barrier integrity in the pathogenesis of Alzheimer's disease

Z Huang, LW Wong, Y Su, X Huang, N Wang… - Frontiers in …, 2020 - Elsevier
bloodbrain barrier (BBB) tightly controls the molecular exchange between the brain parenchyma
and blood. … In this review, we discuss the role of the BBB in maintaining brain integrity

Pericytes are required for bloodbrain barrier integrity during embryogenesis

R Daneman, L Zhou, AA Kebede, BA Barres - Nature, 2010 - nature.com
… in the central nervous system (CNS) form a barrier that restricts the movement of molecules
and ions between the blood and the brain. This bloodbrain barrier (BBB) is crucial to ensure …

Brain edema: a classification based on blood-brain barrier integrity.

AL Betz, F Iannotti, JT Hoff - Cerebrovascular and brain metabolism …, 1989 - europepmc.org
… of brain edema based upon blood-brain barrier integrity is useful to focus research on common
mechanisms for brain … This review considers intact-barrier and open-barrier edema with …

Regulation of bloodbrain barrier integrity by microglia in health and disease: a therapeutic opportunity

PT Ronaldson, TP Davis - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
… to age-related changes in the brain. Indeed, receptors for TGF-β1 are functionally expressed
at the BBB and play a critical role in maintenance of barrier integrity. Members of the TGF-β …