… of the blood–brain barrier, has been shown to transport amyloid-β. P-glycoprotein function
can … The aim of this study was to assess blood–brain barrier P-glycoprotein function in patients …

… , P-gp is a major factor in mediating resistance to brain entry of … This review highlights the
role of altered P-gp function in the … Also the implications of alterations in P-gp function for the …

… P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds
across the blood–brain barrier (BBB). Loss of Pgp function with increasing age may be involved …

… of BBB P-gp function in relation to age. We hypothesised decreased BBB P-gp function with
… We again studied in vivo P-gp function using [ 11 C]-verapamil PET in seventeen healthy …

… brain, increasing the risk of neurodegenerative pathology such as Parkinson’s disease (PD).
This study investigated in vivo BBB P-gp function … as reduced P-gp function. Advanced PD …

… gained in the function of blood–brain barrier P-glycoprotein hold many promises for further
optimization of pharmacotherapy of both diseases localized in the brain and elsewhere in the …

… P-glycoprotein in brain capillary endothelium prevents vincristine from entering the central
nervous system and thus may be one of the functional components of the blood-brain barrier. …

… for a functional role of P-glycoproteln at the blood-brain barrier.. ....… barrier that restricts the
entry of many toxic compounds into … Accordingly, it is suggested that P-gp functions as a barrier …

… blood-brain and blood-cerebrospinal fluid barriers. Its function along the blood-brain barrier
… harmful compounds in the brain by actively removing them from the brain into the peripheral …

… this is because of the inability of many candidate drugs to readily cross the blood–brain
barrier (BBB) and reach sufficiently high concentrations at sites of action within the brain. This …