The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

… blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper, reflecting the
unique requirements of the brain… , we describe its physiology and architecture, which pose …

… Blood enters the brain via surface arteries (red arrow, top). Barriers between blood and …
at three main sites: (1) the brain endothelium forming the blood–brain barrier (BBB), (2) the …

… In this review, we present an overview of the structure and function of the BBB in both
healthy and pathological conditions, the alterations in BBB integrity associated with …

… Blood-brain barrier (BBB) is an anatomical gateway that is an essential requisite for
maintenance of homeostasis and physiological … Therefore, alterations in structure and function of …

… Our knowledge about the structure and function of the BBB and its particular components
is still growing. The importance of studies examining the basic aspects of the BBB is difficult to …

… During physiologic and pathologic changes, TJ structure and function responds quickly to
intracellular signaling events modulating the TJ complexes. Although little is known about the …

… Ehlrich (1885) first described the existence of the blood-brain barrier (BBB). … blood-brain
barrier is an entity located between the blood and brain interstitium, which composed of cerebral …

… Then, we focus on BBB transport physiology including the BBB molecular junctions, endothelial
and pericyte transporters, and perivascular and paravascular transport. Next, we discuss …

… In this chapter, details of the anatomical structure of the BBB, including cellular compartments,
developmental aspects, as well as transport across BBB are discussed. Specific transport …