Bloodbrain barrier dysfunction as a cause and consequence of Alzheimer's disease

MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
… We will also discuss the interaction of the BBB with components of the neurovascular unit in
… of BBB dysfunction. From the results discussed herein, we conclude that BBB dysfunction

The bloodbrain barrier and immune function and dysfunction

WA Banks, MA Erickson - Neurobiology of disease, 2010 - Elsevier
… Here, we will consider four aspects of BBB–neuroimmune interactions: BBB disruption as …
of the bloodbrain barrier (BBB). This review will concentrate on the role the BBB plays in both …

Blood-brain barrier dysfunction in disorders of the developing brain

R Moretti, J Pansiot, D Bettati, N Strazielle… - Frontiers in …, 2015 - frontiersin.org
brain injury. We present an overview of current knowledge about BBB dysfunction in the
developing brain during acute and chronic insults, along with clinical and experimental data. …

The bloodbrain and the blood–cerebrospinal fluid barriers: function and dysfunction

B Engelhardt, L Sorokin - Seminars in immunopathology, 2009 - Springer
… of blood by the bloodbrain barrier (BBB) and the blood–cerebrospinal fluid (CSF)
barrier (BCSFB). While the BBB is … The BBB inhibits the free paracellular diffusion of water-soluble …

Bloodbrain barrier dysfunction and recovery

AG De Boer, PJ Gaillard - Journal of Neural Transmission, 2006 - Springer
… the bloodbrain barrier (BBB) as an interface between blood … of drug transport across the
BBB into the brain, particularly at … as the BBB co-culture system, allows a detailed study of BBB

Bloodbrain barrier dysfunction in brain diseases: Clinical experience

K Schoknecht, H Shalev - Epilepsia, 2012 - Wiley Online Library
… In this article, we briefly recapitulate the role of acute and chronic BBB dysfunction in
stroke, TBI, epilepsy, and schizophrenia; relate to the clinical relevance; and point out future …

Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease

Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
… in the brain. Thus, current evidence suggests that BBB dysfunction may causatively and
consequently contribute to AD pathogenesis, forming a vicious cycle between brain Aβ …

Alzheimer's disease: a matter of bloodbrain barrier dysfunction?

A Montagne, Z Zhao, BV Zlokovic - Journal of Experimental Medicine, 2017 - rupress.org
… , which when disrupted also contribute to a loss of blood-to-brain vascular integrity. We
discuss the role of BBB breakdown and dysfunction in the neurodegenerative process, pitfalls in …

Bloodbrain barrier breakdown is an early biomarker of human cognitive dysfunction

DA Nation, MD Sweeney, A Montagne, AP Sagare… - Nature medicine, 2019 - nature.com
… , it is probably not surprising that BBB dysfunction in the present … of traditional VRFs and BBB
dysfunction in populations with … that brain capillary mural cell damage and BBB breakdown …

Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …

F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
… to BBB dysfunction for the purpose of pharmacologically targeting BMECs. Specifically, we
will outline how the brain endothelial barrier is disrupted by all other brain … to BBB dysfunction, …