The onset of inflammatory bowel diseases (IBD) peaks in adolescents and young adults, but
clinicians are increasingly aware that IBD can occur in very young children, including infants…

… of the disease variance: 13.6% for CD and 7.5% for UC. These figures highlight the need for
critical evaluation of genetic discoveries to … We review recent genetic discoveries in IBD and …

… Insights into disease pathogenesis arising from gene discovery While the application of IBD
susceptibility gene discovery to diagnostic and prognostic systems remains distant, the key …

… Epidemiologic studies long suggested that “disease genes” (genes for which DNA variations
alter disease risk) may cause inflammatory bowel disease (IBD). Crohn's disease (CD) and …

Microbial communities and their associated bioactive compounds 1 , 2 – 3 are often disrupted
in conditions such as the inflammatory bowel diseases (IBD) 4 . However, even in well-…

… (nucleotide-binding oligomerization domain 2)/CARD15 (caspase activation recruitment
domain 15), a landmark discovery in complex disease genetics and the start of a lustrum of …

… to fully realize the promise of genetic discovery in IBD. … The history of discovery in genetics
has taught researchers the value … to additional discovery with respect to genetic influence on …

… scale research studies and gene discovery projects. Whole exome sequencing is a more
cost-efficient strategy for novel disease gene discovery and diagnostics in human genetics. The …

… across the exome and can play a vital role in gene discovery as most Mendelian disorders
appear to result from genetic variation in the exome. This technology is becoming rapidly …

… discovery has provided proof of principle for positional cloning and candidate gene approaches
to identify IBD genes… the genetic basis of inflammatory bowel disease is a realistic goal. …