Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
… introduction of a genetic panel containing these main genes denoted by … microbiota in the
pathogenesis IBD, and its orchestrated interaction with the genetic component of the disease

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

F Imhann, AV Vila, MJ Bonder, J Fu, D Gevers… - Gut, 2018 - gut.bmj.com
… We show for the first time that genetic risk variants associated with IBD influence the gut
microbiota in healthy individuals. Roseburia spp are acetate-to-butyrate converters, and a …

[HTML][HTML] The gut microbiota and inflammatory bowel disease

K Matsuoka, T Kanai - Seminars in immunopathology, 2015 - Springer
genetic status of NOD2 and ATG18L genes, which are two major CD susceptibility genes,
was associated with alteration of the gut microbiota [… is caused by genetic and environmental …

The gut microbiota and inflammatory bowel diseases

J Miyoshi, EB Chang - Translational Research, 2017 - Elsevier
… , as we currently have no measures to correct genetic anomalies. Several microbiome-based
interventions have been studied in IBD, including prebiotics, probiotics, and postbiotics. …

[HTML][HTML] Genetic effects on the commensal microbiota in inflammatory bowel disease patients

H Aschard, V Laville, ET Tchetgen, D Knights… - … genetics, 2019 - journals.plos.org
microbiota have been shown to be associated with inflammatory bowel disease (IBD), and
dozens of IBD genetic … , the role of the microbiota in the etiology of IBD in terms of host genetic

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

H Chu, A Khosravi, IP Kusumawardhani, AHK Kwon… - Science, 2016 - science.org
… interactions during host-microbiota symbiosis, we tested if genetic pathways linked to CD …
autophagy elongation complex; BMDCs deleted in these genes likewise do not induce IL-10 …

[HTML][HTML] The gut microbiota in inflammatory bowel disease

P Qiu, T Ishimoto, L Fu, J Zhang, Z Zhang… - Frontiers in cellular and …, 2022 - frontiersin.org
… There is increasing evidence that the influence of genetic susceptibility and the environment
on gut microbiota is also related to the pathogenesis of IBD (Figure 1 and Table 1). …

[HTML][HTML] Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
… Although etiology remains largely unknown, recent research has suggested that genetic
factors, environment, microbiota, and immune response are involved in the pathogenesis. …

[HTML][HTML] New frontiers in genetics, gut microbiota, and immunity: a rosetta stone for the pathogenesis of inflammatory bowel disease

M Zhou, J He, Y Shen, C Zhang, J Wang… - BioMed research …, 2017 - hindawi.com
… environment, internal gut microbiota, and the … microbiota in genetically susceptibility
individuals. The past decade has witnessed the flourishing of research on genetics, gut microbiota, …

Genetics and pathogenesis of inflammatory bowel disease

B Khor, A Gardet, RJ Xavier - Nature, 2011 - nature.com
Genetic variants, the microbiota and immune factors affect the balance of these signals. …
intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, …