Y Yang, H Musco, S Simpson-Yap, Z Zhu… - Nature …, 2021 - nature.com
… colitis (UC) and Crohn’s disease (CD), remains unclear. Here, … geneticarchitecture between MS and IBD overall and UC and CD independently. We find a significantly greater genetic …
… geneticarchitecture of the inflammatory boweldiseases ulcerative colitis and Crohn's disease, … , damaging missense variants in known Crohn's disease risk genes, suggesting that more …
… Crohn’s disease and ulcerative colitis, the two common forms of inflammatory boweldisease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
I Cleynen, S Vermeire - Current opinion in gastroenterology, 2015 - journals.lww.com
Genetic, transcriptomic and epigenetic studies have offered exciting clues about IBD pathogenesis but are unlikely to provide all answers. To fully grasp the function of disease-…
J Ostrowski, A Paziewska, I Lazowska… - Scientific reports, 2016 - nature.com
… Most inflammatory boweldiseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the geneticarchitecture of pediatric and adult-onset …
… , suggesting that the geneticarchitecture of disease severity may be distinct from the … disease severity and on the main research venues to decipher the geneticarchitecture of disease …
… (3) lack of molecular insights into established genetic signals—as most association signals … geneticarchitectures across populations. Genetic discoveries of inflammatory boweldisease …
R Zeng, J Wang, R Jiang, J Yang, C Zheng… - … and Disease, 2023 - ncbi.nlm.nih.gov
… Our findings indicate possible shared geneticarchitecture and pathways between ALS and IBD. These results provide insights into the pathogenesis and therapeutics of IBD and …
… UC) demonstrated increased genetic correlations for psychiatric-… reveals the shared genetic architecture between multiple … diseases may moderate management of these diseases for …