… Comparative genetic architecture across ancestries We first compared the IBD genetic
architecture for common variants across the following three EAS samples: Chinese (SHA1), …

… colitis (UC) and Crohn’s disease (CD), remains unclear. Here, … genetic architecture between
MS and IBD overall and UC and CD independently. We find a significantly greater genetic …

… genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease,
… , damaging missense variants in known Crohn's disease risk genes, suggesting that more …

… Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Genetic, transcriptomic and epigenetic studies have offered exciting clues about IBD
pathogenesis but are unlikely to provide all answers. To fully grasp the function of disease-…

… Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by
common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset …

… , suggesting that the genetic architecture of disease severity may be distinct from the …
disease severity and on the main research venues to decipher the genetic architecture of disease …

… (3) lack of molecular insights into established genetic signals—as most association signals
… genetic architectures across populations. Genetic discoveries of inflammatory bowel disease …

… Our findings indicate possible shared genetic architecture and pathways between ALS
and IBD. These results provide insights into the pathogenesis and therapeutics of IBD and …

… UC) demonstrated increased genetic correlations for psychiatric-… reveals the shared genetic
architecture between multiple … diseases may moderate management of these diseases for …