Microglial activation and tau propagate jointly across Braak stages

TA Pascoal, AL Benedet, NJ Ashton, MS Kang… - Nature medicine, 2021 - nature.com
… signal of microglia activation imaging 14,15,16 and a tau imaging agent capable of capturing
… and late Braak stages 17,18 , we studied the association between microglial activation and …

Microglial activation occurs late during preclinical Alzheimer's disease

WJ Streit, H Braak, K Del Tredici, J Leyh, J Lier… - Glia, 2018 - Wiley Online Library
… mouse models, microglial activation does not seem to be part of late-stage AD in humans (…
disease stages in nondemented subjects to determine the onset of microglial activation during …

Publisher Correction: Microglial activation and tau propagate jointly across Braak stages

TA Pascoal, AL Benedet, NJ Ashton, MS Kang… - Nature medicine, 2021 - nature.com
In the version of this article initially published, the Acknowledgements section was missing
the following sentence:‘The authors acknowledge the technical collaboration and financial …

Microglia in Alzheimer brain: a neuropathological perspective

RE Mrak - International journal of Alzheimer's disease, 2012 - Wiley Online Library
… a slight decrease in microglial activation in end-stage (Braak and Braak stage VI) … Braak
and Braak stages [42]. The concurrent absence of microglia and dystrophic neurites in end-stage

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

WJ Streit, H Braak, QS Xue, I Bechmann - Acta neuropathologica, 2009 - Springer
… ) rather than with activated microglial cells. Using Braak staging of Alzheimer neuropathology
… Our findings also indicate that when microglial activation does occur in the absence of an …

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
… disease — for example, the spread of tau pathology according to the Braak staging
system — might be related to local microglial phenotypes 93 . Indeed, regional diversity of …

Microglial activation and connectivity in Alzheimer disease and aging

BS Rauchmann, M Brendel, N Franzmeier… - Annals of …, 2022 - Wiley Online Library
… Previous research indicates that microglial activation is … in a Braak stage-like fashion;
furthermore, microglial activation … of microglial and tau tracer uptake on PET, the Braak stage-like …

[HTML][HTML] Microglia in Alzheimer's disease: activated, dysfunctional or degenerative

V Navarro, E Sanchez-Mejias, S Jimenez… - Frontiers in aging …, 2018 - frontiersin.org
microglial activation. Beside this differential response, we also observed microglial degeneration
in Braak … are surrounded by activated microglia, however in late stage AD (Braak V–VI) …

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

J Brettschneider, DJ Libon, JB Toledo, SX Xie… - Acta …, 2012 - Springer
… One patient showed tau pathology consistent with Braak stage III–IV [7, 8] and Aβ pathology
with a CERAD score B [43, 55]. Thus, we identified one patient in our cohort who had co-…

Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer's disease pathology

JB Pereira, S Janelidze, O Strandberg, CD Whelan… - Nature aging, 2022 - nature.com
… In other words, microglial activation slowed down the neocortical Braak III–VI stages of the …
that showed a protective role of microglial activation in reducing the accumulation of insoluble …