Bile acids: a communication channel in the gut-brain axis

VF Monteiro-Cardoso, M Corlianò… - NeuroMolecular …, 2021 - Springer
… Although bile acids may be synthesized locally in the brain, the majority of brain bile acids
are taken up from the systemic circulation. Since the composition of the brain bile acid pool …

Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer's disease

A Mulak - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Bile acid modulatory effects on the brain-gut-microbiota axis in Alzheimer’s disease. Bile
acids (BAs) may act as modulators of each level of the brain-gut-microbiota axis. There are …

Expert insights: the potential role of the gut microbiome‐bile acidbrain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy

W Jia, C Rajani, R Kaddurah‐Daouk… - Medicinal research …, 2020 - Wiley Online Library
… In conclusion, targeting the gut microbiome-BA-brain axis may be a possible new anti-AD/HE
strategy. Future investigations may include the effects of decreasing the amount of BAs in …

Gut-microbiota-brain axis by bile acids in depression

K Hashimoto - Psychiatry Clin Neurosci, 2022 - search.ebscohost.com
… metabolism of bile acids, resulting in depressive symptoms through systemic inflammation.
Finally, this study suggests the new role of bile acid-gut-microbiota-brain axis in depression, …

[HTML][HTML] A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

S Liu, G Marcelin, C Blouet, JH Jeong, YH Jo… - Molecular …, 2018 - Elsevier
Bile acids have been … As bile acids stimulate the release of FGF19/FGF15 into the circulation,
we pursued the potential of bile acids to improve glucose tolerance via a gut–brain axis

[HTML][HTML] Bile acid receptors and signaling crosstalk in the liver, gut and brain

JM Ferrell, JYL Chiang - Liver Research, 2021 - Elsevier
bile acid receptors in the blood-brain barrier and in the brain itself. This review highlights the
role of bile acids … their function as mediators of cellular signaling in the liver-gut-brain axis. …

[HTML][HTML] Bile acids and neurological disease

MJ Hurley, R Bates, J Macnaughtan… - Pharmacology & …, 2022 - Elsevier
… This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

W Dong, Y Huang, Y Shu, X Fan, X Tian, Y Yan, J Mi… - Food & Function, 2023 - pubs.rsc.org
The high-fat and high-fructose diet (HFFD) is a common diet in westernized societies, which
worsens disturbances in gut microbiota and bile acid (BA) metabolism. Herein, the present …

Microbiota-gut-brain axis in the Alzheimer's disease pathology-an overview

VV Giridharan, CEB De Quevedo, F Petronilho - Neuroscience Research, 2022 - Elsevier
… (AHRs), bile acids, and the hypothalamic-pituitary-adrenal (HPA) axis. In this narrative
review, we explore and clarify the involvement of the microbiota-gut-brain axis in AD pathology. …

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—an emerging role for gut microbiome

S MahmoudianDehkordi, M Arnold, K Nho… - Alzheimer's & …, 2019 - Elsevier
… Increasing evidence suggests a role for the gut microbiome in central nervous system disorders
and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products …